Background Breathlessness is a common and disabling symptom which affects many
people with advanced cardiorespiratory disease and cancer. The most effective treatments …

It has been argued that emotion, pain and cognitive control are functionally segregated in
distinct subdivisions of the cingulate cortex. However, recent observations encourage a …

▪ Abstract Depression is a disorder of the representation and regulation of mood and
emotion. The circuitry underlying the representation and regulation of normal emotion and …

A wealth of animal data implicates the amygdala in aspects of emotional processing. In
recent years, functional neuroimaging and neuropsychological studies have begun to refine …

Respiratory depression limits the use of opioid analgesia. Although well described clinically,
the specific mechanisms of opioid action on respiratory control centres in the brain have …

This review and meta-analysis aims at summarizing and integrating the human
neuroimaging studies that report periaqueductal gray (PAG) involvement; 250 original …

The amygdala processes and directs inputs and outputs that are key to fear behavior.
However, whether it directly senses fear-evoking stimuli is unknown. Because the amygdala …

Despite the brain's central role in sexual function, little is known about relationships between
brain activation and sexual response. In this study, we employed functional MRI (fMRI) to …

Effective management of dyspnea in chronic obstructive pulmonary disease (COPD)
requires a clearer understanding of its underlying mechanisms. This roundtable reviews …

Objective To test the hypothesis that aerobic exercise is associated with improvements in
cognition and cerebrovascular regulation, we enrolled 206 healthy low-active middle-aged …