Aging is a major risk factor in the development of chronic diseases affecting various tissues
including the cardiovascular system, muscle and bones. Age-related diseases are a …

Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …

In mammals, aging is associated with accumulation of senescent cells. Stresses such as
telomere shortening and reactive oxygen species induce “cellular senescence”, which is …

Telomeres are the protective end caps of chromosomes and shorten with every cell division.
Telomere length has been proposed as a biomarker of biological age and a risk factor for …

Telomeres are tandem repeat DNA sequences present at the ends of each eukaryotic
chromosome to stabilize the genome structure integrity. Telomere lengths progressively …

Background—Mitochondrial DNA (mtDNA) damage occurs in both circulating cells and the
vessel wall in human atherosclerosis. However, it is unclear whether mtDNA damage …

Telomeres are at the non-coding ends of linear chromosomes. Through a complex 3-
dimensional structure, they protect the coding DNA and ensure appropriate separation of …

Atherosclerosis is one of the main underlying causes of cardiovascular diseases (CVD). It is
associated with chronic inflammation and intimal thickening as well as the involvement of …

Atherosclerosis is a disease of ageing in that its incidence and prevalence increase with
age. However, atherosclerosis is also associated with biological ageing, manifest by a …

Atherosclerosis is an age-related disorder associated with long-term exposure to
cardiovascular risk factors. The asymptomatic progression of atherosclerotic plaques leads …