Gamma secretase modulators: new Alzheimer's drugs on the horizon?
MG Bursavich, BA Harrison… - Journal of medicinal …, 2016 - ACS Publications
The rapidly aging population desperately requires new therapies for Alzheimer's disease.
Despite years of pharmaceutical research, limited clinical success has been realized, with …
Despite years of pharmaceutical research, limited clinical success has been realized, with …
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease
Innate immunity is associated with Alzheimer's disease, but the influence of immune
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond
B De Strooper… - Annual review of …, 2015 - annualreviews.org
γ-Secretases are a group of widely expressed, intramembrane-cleaving proteases involved
in many physiological processes. Their clinical relevance comes from their involvement in …
in many physiological processes. Their clinical relevance comes from their involvement in …
A three-dimensional human neural cell culture model of Alzheimer's disease
SH Choi, YH Kim, M Hebisch, C Sliwinski, S Lee… - Nature, 2014 - nature.com
Alzheimer's disease is the most common form of dementia, characterized by two
pathological hallmarks: amyloid-β plaques and neurofibrillary tangles. The amyloid …
pathological hallmarks: amyloid-β plaques and neurofibrillary tangles. The amyloid …
[HTML][HTML] Structural basis of γ-secretase inhibition and modulation by small molecule drugs
Development of γ-secretase inhibitors (GSIs) and modulators (GSMs) represents an
attractive therapeutic opportunity for Alzheimer's disease (AD) and cancers. However, how …
attractive therapeutic opportunity for Alzheimer's disease (AD) and cancers. However, how …
Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease
Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring
therapy of cancer and other diseases in preclinical studies; however, this technology has not …
therapy of cancer and other diseases in preclinical studies; however, this technology has not …
A Photolabile Curcumin‐Diazirine Analogue Enables Phototherapy with Physically and Molecularly Produced Light for Alzheimer's Disease Treatment
The development of Alzheimer's disease (AD) drugs has recently witnessed substantial
achievement. To further enhance the pool of drug candidates, it is crucial to explore non …
achievement. To further enhance the pool of drug candidates, it is crucial to explore non …
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention
KD Rynearson, M Ponnusamy, O Prikhodko… - Journal of Experimental …, 2021 - rupress.org
A potent γ-secretase modulator (GSM) has been developed to circumvent problems
associated with γ-secretase inhibitors (GSIs) and to potentially enable use in primary …
associated with γ-secretase inhibitors (GSIs) and to potentially enable use in primary …
Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1–induced pluripotent stem cell mutant carriers
Q Liu, S Waltz, G Woodruff, J Ouyang, MA Israel… - JAMA …, 2014 - jamanetwork.com
Importance Although considerable effort has been expended developing drug candidates
for Alzheimer disease, none have yet succeeded owing to the lack of efficacy or to safety …
for Alzheimer disease, none have yet succeeded owing to the lack of efficacy or to safety …
Recent developments of small molecule γ-secretase modulators for Alzheimer's disease
S Mekala, G Nelson, YM Li - RSC Medicinal Chemistry, 2020 - pubs.rsc.org
Alzheimer's disease (AD) is the most common form of progressive neurodegenerative
disorder, marked by memory loss and a decline in cognitive function. The major hallmarks of …
disorder, marked by memory loss and a decline in cognitive function. The major hallmarks of …