Helicobacter infection is the leading cause of gastric cancer worldwide. Infection with this
ubiquitous bacterium incites a chronic active immune response that persists for the life of the …

Intestinal metaplasia (IM) of the gastric mucosa is a relatively frequent precancerous lesion
(1). The inclusion of IM in a gastric biopsy pathology report often creates uncertainty for the …

Barrett's esophagus is an intestine-like metaplasia and precursor of esophageal
adenocarcinoma. Triggered by gastroesophageal reflux disease, the origin of this …

Objective Helicobacter pylori strains that express the oncoprotein CagA augment risk for
gastric cancer. However, the precise mechanisms through which cag+ strains heighten …

The gastrointestinal tract of complex metazoans is highly compartmentalized. It is lined by a
series of specialized epithelia that are regenerated by specific populations of stem cells. To …

Gastric intestinal metaplasia (GIM) is a known premalignant condition of the human stomach
along the pathway to gastric cancer (GC). Histologically, GIM represents the replacement of …

The membrane-bound mucins belong to an ever-increasing family of O-glycoproteins.
Based on their structure and localization at the cell surface they are thought to play important …

Barrett's esophagus (BE) and gastric intestinal metaplasia are related premalignant
conditions in which areas of human stomach epithelium express mixed gastric and intestinal …

Background & Aims Although pancreatic cystic lesions (PCLs) are frequently and
incidentally detected, it is a challenge to determine their risk of malignancy. In …

Simple Summary Esophageal and esophago-gastric junction adenocarcinomas (EA/EGJAs)
are a heterogeneous group of cancers. Stage is the most important prognostic factor, while …