Inflammation is an adaptive response of the immune system to noxious insults to maintain
homeostasis and restore functionality. The retina is considered an immune-privileged tissue …

Activation of the complement system is a major pathogenic event that drives various
inflammatory responses in numerous diseases. All pathways of complement activation lead …

The complement system has been involved in the pathogenesis of multiple
neuroinflammatory and neurodegenerative conditions. In this review, we evaluated the …

Multiple sclerosis (MS) is a demyelinating disease characterized by chronic inflammation of
the central nervous system, in which many factors can act together to influence disease …

Animal models of multiple sclerosis (MS) have been extensively used to characterize the
disease mechanisms in MS, as well as to identify potential pharmacologic targets for this …

Cholesterol is essential to the functions of the brain, which contains approximately 20% of
the body's stores of this sterol. Most brain cholesterol is found in compacted myelin. The …

Oxidative stress (OS) and inflammation play a key role in the development of hypoxic–
ischemic (H–I) induced brain damage. Following H–I, rapid neuronal death occurs during …

Objective: This study aims to assess the protective effect of berberine against neuronal
damage in the brain parenchyma of mice with experimental autoimmune encephalomyelitis …

Neuromyelitis optica (NMO) and multiple sclerosis (MS) are two of the autoimmune
inflammatory demyelinating diseases in the central nervous system. Complement is thought …

Abstract MOG35-55 triggers chronic, progressive experimental autoimmune
encephalomyelitis (EAE) in C57BL/6 mice, and the clinical course of EAE in this model is …