Asthma is one of the most common respiratory disease that affects both children and adults
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …

It has become clear that early life (including in utero exposures) is a key window of
vulnerability during which environmental exposures can alter developmental trajectories …

Several DNA methylation clocks have been developed to reflect chronological age of human
tissues, but most clocks have been trained on adult samples. The rapid methylome changes …

Background When designing an epigenome-wide association study (EWAS) to investigate
the relationship between DNA methylation (DNAm) and some exposure (s) or phenotype (s) …

Background Limited data are available on prevalence and associated risk factors for atopy
and allergic diseases from high-altitude urban settings in Latin America. Objective To …

Epithelial barrier tissues such as the skin and airway form an essential interface between the
mammalian host and its external environment. These physical barriers are crucial to prevent …

Allergic diseases, characterized by a broad spectrum of clinical manifestations and
symptoms, encompass a significant category of IgE-mediated atopic disorders, including …

Childhood asthma is a chronic heterogeneous syndrome consisting of different disease
entities or phenotypes. The immunologic and cellular processes that occur during asthma …

Background IgE‐mediated food allergies have been linked to suboptimal naïve CD4 T
(nCD4T) cell activation in infancy, underlined by epigenetic and transcriptomic variation …

Asthma is the most common non-communicable chronic disease of childhood. Despite its
high prevalence, to date we lack methods that are both efficient and accurate in diagnosing …