Cancer is one of the greatest causes of death worldwide. With the development of surgery,
radiotherapy, and medical agents, the outcomes of cancer patients have greatly improved …

Cervical cancer is associated with infection by certain types of human papillomaviruses
(HPVs), and this affects women worldwide. Despite the improvements in prevention and …

Krüppel-associated box zinc finger proteins (KRAB-ZFPs) constitute the largest family of
transcriptional factors exerting co-repressor functions in mammalian cells. In general, KRAB …

During the last decade, high-throughput sequencing efforts in the fields of transcriptomics
and epigenomics have shed light on the noncoding part of the transcriptome and its …

Abstract Dysfunction of Tumour Suppressor Genes (TSGs) is a common feature in
carcinogenesis. Epigenetic abnormalities including DNA hypermethylation or aberrant …

Folate is a B-vitamin with an important role in health and disease. The optimal folate status
with regard to human health remains controversial. A low intake of natural folate as well as …

In most diagnostic laboratories, targeted next-generation sequencing (NGS) is currently the
default assay for the detection of somatic variants in solid as well as haematological …

Lysine acetylation is one of the major posttranslational modifications (PTM) in human cells
and thus needs to be tightly regulated by the writers of this process, the histone acetyl …

FADD was initially described as an adaptor molecule for death receptor-mediated apoptosis,
but subsequently it has been implicated in nonapoptotic cellular processes such as …

Background Epigenetic modifiers, such as methyltransferases, play crucial roles in the
regulation of many biological processes, including development, cancer and multiple …