Background: To date, health-effects research on environmental stressors has rarely focused
on behavioral and mental health outcomes. That lack of research is beginning to change …

Epidemiological and clinical studies have suggested that the pathogenesis of inflammatory
bowel disease (IBD) is strongly influenced by genetic predisposition. Beyond the limitations …

Inborn errors of immunity (IEIs) are immunological disorders characterized by variable
susceptibility to infections, immune dysregulation and/or malignancies, as a consequence of …

Abstract Aim Type 2 diabetes (T2DM) is a complex disease. Interactions between genetic
susceptible variants and environmental cues results in the development of this …

Identifying genetic risk factors for lumbar spine disorders may lead to knowledge regarding
underlying mechanisms and the development of new treatments. We conducted a genome …

Background Despite significant advances in the understanding and treatment of obsessive
compulsive disorder (OCD), current treatment options are limited in terms of efficacy for …

Growing virus resistant varieties is a highly effective means to avoid yield loss due to
infection by many types of virus. The challenge is to be able to detect resistance donors …

Objectives Besides adaptive immunity genes, genetic risk factors for psoriatic arthritis (PsA)
include innate immunity loci, which suggests an autoinflammatory disease mechanism, at …

Abstract SPOT (http://spot. cgsmd. isi. edu), the SNP prioritization online tool, is a web site for
integrating biological databases into the prioritization of single nucleotide polymorphisms …

Recently, biologists have argued that data-driven biology fosters a new scientific
methodology, namely, one that is irreducible to traditional methodologies of molecular …