Parkinson's disease is a common progressive neurodegenerative disease, and presently
has no curative agent. Curcumin, as one of the natural polyphenols, has great potential in …

Parkinson's disease (PD) is known as a mitochondrial disease. Some even regarded it
specifically as a disorder of the complex I of the electron transport chain (ETC). The ETC is …

Background: Parkinson's disease (PD) is an increasing challenge to public health. Tracking
the temporal trends of PD burden would inform health strategies. Methods: Data of PD …

Abstract Endocannabinoid (eCB), 2-arachidonoyl-glycerol (2-AG), the most abundant eCB in
the brain, regulates diverse neural functions. Here we linked multiple homozygous loss-of …

Genome-wide association studies (GWASs) have identified numerous susceptibility loci for
Parkinson's disease (PD), but its genetic architecture remains underexplored in populations …

Abstract Background Parkin RBR E3 ubiquitin‐protein ligase (PRKN) mutations are the most
common cause of young onset and autosomal recessive Parkinson's disease (PD). PRKN is …

Abstract In 2016, the Movement Disorder Society Task Force for the Nomenclature of
Genetic Movement Disorders presented a new system for naming genetically determined …

Fundamentally, the identification of causes and contributors of disease represents the first
step in an etiology-based understanding of disease. This, in turn, is a required step in the …

A growing amount of evidence has indicated contributions of variants in causative genes of
Parkinson's disease (PD) to the development of sleep disturbance in PD and prodromal PD …

GBA1 variants are important risk factors for Parkinson's disease (PD). Most studies
assessing GBA1-related PD risk have been performed in European-derived populations …