Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …
Physics of adherent cells
US Schwarz, SA Safran - Reviews of Modern Physics, 2013 - APS
One of the most unique physical features of cell adhesion to external surfaces is the active
generation of mechanical force at the cell-material interface. This includes pulling forces …
generation of mechanical force at the cell-material interface. This includes pulling forces …
Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness
Single cardiomyocytes contain myofibrils that harbor the sarcomere-based contractile
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem …
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem …
Long-range self-organization of cytoskeletal myosin II filament stacks
Although myosin II filaments are known to exist in non-muscle cells,, their dynamics and
organization are incompletely understood. Here, we combined structured illumination …
organization are incompletely understood. Here, we combined structured illumination …
Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating
In development and differentiation, morphological changes often accompany mechanical
changes [1], but it is unclear whether or when cells in embryos sense tissue elasticity. The …
changes [1], but it is unclear whether or when cells in embryos sense tissue elasticity. The …
Living matter: mesoscopic active materials
A Bernheim‐Groswasser, NS Gov… - Advanced …, 2018 - Wiley Online Library
An introduction to the physical properties of living active matter at the mesoscopic scale
(tens of nanometers to micrometers) and their unique features compared with “dead,” …
(tens of nanometers to micrometers) and their unique features compared with “dead,” …
Striated myocyte structural integrity: Automated analysis of sarcomeric z-discs
As sarcomeres produce the force necessary for contraction, assessment of sarcomere order
is paramount in evaluation of cardiac and skeletal myocytes. The uniaxial force produced by …
is paramount in evaluation of cardiac and skeletal myocytes. The uniaxial force produced by …
Matrix mechanosensing: from scaling concepts in'omics data to mechanisms in the nucleus, regeneration, and cancer
Many of the most important molecules of life are polymers. In animals, the most abundant of
the proteinaceous polymers are the collagens, which constitute the fibrous matrix outside …
the proteinaceous polymers are the collagens, which constitute the fibrous matrix outside …
Delineating the heterogeneity of matrix-directed differentiation toward soft and stiff tissue lineages via single-cell profiling
Mesenchymal stromal/stem cells (MSCs) form a heterogeneous population of multipotent
progenitors that contribute to tissue regeneration and homeostasis. MSCs assess …
progenitors that contribute to tissue regeneration and homeostasis. MSCs assess …
Matrix mechanics and regulation of the fibroblast phenotype
B Hinz - Periodontology 2000, 2013 - Wiley Online Library
The oral cavity hosts a variety of different fibroblast populations that are generally
responsible for maintaining homeostasis of the soft connective tissue. In addition to …
responsible for maintaining homeostasis of the soft connective tissue. In addition to …