Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …
formalized, transparent and quality-controlled way, mechanistic information to apical …
[HTML][HTML] t4 workshop report: State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology
N Alépée, A Bahinski, M Daneshian, B De Wever… - Altex, 2014 - ncbi.nlm.nih.gov
Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …
g: Profiler—a web server for functional interpretation of gene lists (2016 update)
Functional enrichment analysis is a key step in interpreting gene lists discovered in diverse
high-throughput experiments. g: Profiler studies flat and ranked gene lists and finds …
high-throughput experiments. g: Profiler studies flat and ranked gene lists and finds …
Human pluripotent stem cell-derived neural constructs for predicting neural toxicity
Human pluripotent stem cell-based in vitro models that reflect human physiology have the
potential to reduce the number of drug failures in clinical trials and offer a cost-effective …
potential to reduce the number of drug failures in clinical trials and offer a cost-effective …
Using zebrafish in systems toxicology for developmental toxicity testing
Y Nishimura, A Inoue, S Sasagawa… - Congenital …, 2016 - Wiley Online Library
With the high cost and the long‐term assessment of developmental toxicity testing in
mammals, the vertebrate zebrafish has become a useful alternative model organism for high …
mammals, the vertebrate zebrafish has become a useful alternative model organism for high …
[HTML][HTML] Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2
Development of novel approaches for regulating the expression of angiotensin-converting
enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) is becoming …
enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) is becoming …
Toxicokinetic triage for environmental chemicals
JF Wambaugh, BA Wetmore, R Pearce… - Toxicological …, 2015 - academic.oup.com
Toxicokinetic (TK) models link administered doses to plasma, blood, and tissue
concentrations. High-throughput TK (HTTK) performs in vitro to in vivo extrapolation to …
concentrations. High-throughput TK (HTTK) performs in vitro to in vivo extrapolation to …
[HTML][HTML] Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their …
M Aschner, S Ceccatelli, M Daneshian, E Fritsche… - Altex, 2017 - ncbi.nlm.nih.gov
There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …
posed by industrial and environmental chemicals. New testing approaches will most likely …
[HTML][HTML] Food for Thought…: Developmental Neurotoxicity–Challenges in the 21st Century and In Vitro Opportunities
In recent years neurodevelopmental problems in children have increased at a rate that
suggests lifestyle factors and chemical exposures as likely contributors. When …
suggests lifestyle factors and chemical exposures as likely contributors. When …
In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
BZ Schmidt, M Lehmann, S Gutbier, E Nembo… - Archives of …, 2017 - Springer
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …
assessment. Since the interpretation of animal data and their extrapolation to man is …