The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators …

Plants are sessile organisms, some of which can live for over a thousand years. Unlike most
animals, plants employ a post-embryonic mode of development driven by the continuous …

During eukaryotic transcription elongation, RNA polymerase II (RNAP2) is regulated by a
chorus of factors. Here, we identified a common binary interaction module consisting of TFIIS …

A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS)
to glycolysis, a phenomenon referred to as the 'Warburg effect', which is also observed in …

The ubiquitin–proteasome system regulates a variety of cellular processes including growth,
differentiation and apoptosis. While E1, E2, and E3 are responsible for the conjugation of …

Activated hepatic stellate cells (HSCs) are the major cell type involved in the deposition of
extracellular matrix (ECM) during the development of hepatic fibrosis. In this study, we …

Analyses of gene expression in single mouse embryonic stem cells (mESCs) cultured in
serum and LIF revealed the presence of two distinct cell subpopulations with individual gene …

Oxygen deprivation induces a range of cellular adaptive responses that enable to drive
cancer progression. Here, we report that lysine‐specific demethylase 1 (LSD 1) upregulates …

Significant progress has been made in the last decade in our understanding of the
pathogenetic mechanisms of colorectal cancer (CRC). Cancer stem cells (CSC) have …

Because of their nuclear dimorphism, ciliates provide a unique opportunity to study the role
of non-coding RNAs (ncRNAs) in the communication between germline and somatic …