Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
Autophagy in kidney homeostasis and disease
C Tang, MJ Livingston, Z Liu, Z Dong - Nature Reviews Nephrology, 2020 - nature.com
Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …
[HTML][HTML] Mechanisms leading to differential hypoxia-inducible factor signaling in the diabetic kidney: modulation by SGLT2 inhibitors and hypoxia mimetics
M Packer - American Journal of Kidney Diseases, 2021 - Elsevier
Sodium/glucose cotransporter 2 (SGLT2) inhibitors exert important renoprotective effects in
the diabetic kidney, which cannot be readily explained by their actions to lower blood …
the diabetic kidney, which cannot be readily explained by their actions to lower blood …
Highlighting diabetes mellitus: the epidemic continues
AM Schmidt - Arteriosclerosis, thrombosis, and vascular biology, 2018 - Am Heart Assoc
Prompted by the observation that atherosclerotic plaques from human diabetic subjects
displayed lower amounts of NADPH (nicotinamide adenine dinucleotide phosphate) …
displayed lower amounts of NADPH (nicotinamide adenine dinucleotide phosphate) …
[HTML][HTML] Exploring the role of autophagy-related gene 5 (ATG5) yields important insights into autophagy in autoimmune/autoinflammatory diseases
Autophagy is a highly conserved process that degrades certain intracellular contents in both
physiological and pathological conditions. Autophagy-related proteins (ATG) are key players …
physiological and pathological conditions. Autophagy-related proteins (ATG) are key players …
Mechanisms of podocyte injury and implications for diabetic nephropathy
F Barutta, S Bellini, G Gruden - Clinical Science, 2022 - portlandpress.com
Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies,
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …
including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and …
Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential
D Yang, MJ Livingston, Z Liu, G Dong, M Zhang… - Cellular and Molecular …, 2018 - Springer
Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious
public health problem worldwide and lacks effective therapies. Autophagy is a highly …
public health problem worldwide and lacks effective therapies. Autophagy is a highly …
[HTML][HTML] Knowledge domain and emerging trends in podocyte injury research from 1994 to 2021: a bibliometric and visualized analysis
T Liu, L Yang, H Mao, F Ma, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Background: Podocyte injury has a direct causal relationship with proteinuria and
glomerulosclerosis and, on a chronic level, can lead to irreversible disease progression …
glomerulosclerosis and, on a chronic level, can lead to irreversible disease progression …
[HTML][HTML] Mesenchymal stem cell-derived exosomes ameliorated diabetic nephropathy by autophagy induction through the mTOR signaling pathway
Background: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and a
common cause of end-stage renal disease. Autophagy has a defensive role against kidney …
common cause of end-stage renal disease. Autophagy has a defensive role against kidney …
Therapeutic inhibition of VEGF signaling and associated nephrotoxicities
CC Estrada, A Maldonado… - Journal of the American …, 2019 - journals.lww.com
Inhibition of vascular endothelial growth factor A (VEGFA)/vascular endothelial growth factor
receptor 2 (VEGFR2) signaling is a common therapeutic strategy in oncology, with new …
receptor 2 (VEGFR2) signaling is a common therapeutic strategy in oncology, with new …