Osteoarthritis (OA) as a debilitating affliction of joints currently affects millions of people and
remains an unsolved problem. The disease involves multiple cellular and molecular …

Organic anion transporting polypeptides (OATP) 1B1 and OATP1B3 are important hepatic
transporters that mediate the uptake of many clinically important drugs, including statins from …

Ubiquitination has important functions in osteoarthritis (OA), yet the mechanism remains
unclear. Here, we identify the regulator of G protein signaling 12 (RGS12) in macrophages …

Spermidine has been known to inhibit the production of pro-inflammatory cytokines.
However, there are no reports about anti-inflammatory effects of spermidine on osteoarthritis …

Post-translational modifications (PTMs) by ubiquitin (Ub) are versatile, highly dynamic, and
involved in nearly all aspects of eukaryote biological function. The reversibility and …

Ageing is characterized by a progressive loss of cellular function that leads to a decline in
tissue homeostasis, increased vulnerability and adverse health outcomes. Important …

Osteoarthritis (OA), the most common form of arthritis, is a very common joint disease that
often affects middle-aged to elderly people. However, current treatment options for OA are …

Ubiquitin‐binding domains (UBDs) are modular units found within ubiquitin‐binding proteins
that mediate the non‐covalent recognition of (poly) ubiquitin modifications. A variety of …

ITCH is an E3 ubiquitin ligase associated with some inflammatory diseases, but its role in
osteoarthritis (OA) remains to be explored. Here, we investigated the effects of ITCH in OA …

Abnormal expression of KDM6A and SOX9 is a key factor in the pathogenesis of
osteoarthritis (OA). Cellular treatments of OA with articular cartilage chondrocytes (ACCs) …