Molecular mechanisms of inflammasome activation during microbial infections
P Broz, DM Monack - Immunological reviews, 2011 - Wiley Online Library
The innate immune system plays a crucial role in the rapid recognition and elimination of
invading microbes. Detection of microbes relies on germ‐line encoded pattern recognition …
invading microbes. Detection of microbes relies on germ‐line encoded pattern recognition …
Mechanisms of Francisella tularensis intracellular pathogenesis
J Celli, TC Zahrt - Cold Spring Harbor …, 2013 - perspectivesinmedicine.cshlp.org
Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …
Subversion of host recognition and defense systems by Francisella spp
CL Jones, BA Napier, TR Sampson… - Microbiology and …, 2012 - Am Soc Microbiol
Francisella tularensis is a Gram-negative intracellular pathogen and the causative agent of
the disease tularemia. Inhalation of as few as 10 bacteria is sufficient to cause severe …
the disease tularemia. Inhalation of as few as 10 bacteria is sufficient to cause severe …
Elevated AIM2‐mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis
K Peng, P Broz, J Jones, LM Joubert… - Cellular …, 2011 - Wiley Online Library
Intracellular bacterial pathogens Francisella novicida and the Live Vaccine Strain (LVS) are
recognized in the macrophage cytosol by the AIM2 inflammasome, which leads to the …
recognized in the macrophage cytosol by the AIM2 inflammasome, which leads to the …
Abundance and co-occurrence of extracellular capsules increase environmental breadth: Implications for the emergence of pathogens
O Rendueles, M Garcia-Garcerà, B Néron… - PLoS …, 2017 - journals.plos.org
Extracellular capsules constitute the outermost layer of many bacteria, are major virulence
factors, and affect antimicrobial therapies. They have been used as epidemiological markers …
factors, and affect antimicrobial therapies. They have been used as epidemiological markers …
Host defense and the airway epithelium: frontline responses that protect against bacterial invasion and pneumonia
NA Eisele, DM Anderson - Journal of pathogens, 2011 - Wiley Online Library
Airway epithelial cells are the first line of defense against invading microbes, and they
protect themselves through the production of carbohydrate and protein matrices …
protect themselves through the production of carbohydrate and protein matrices …
From the Outside-In: The Francisella tularensis Envelope and Virulence
HM Rowe, JF Huntley - Frontiers in cellular and infection microbiology, 2015 - frontiersin.org
Francisella tularensis is a highly-infectious bacterium that causes the rapid, and often lethal
disease, tularemia. Many studies have been performed to identify and characterize the …
disease, tularemia. Many studies have been performed to identify and characterize the …
Trogocytosis-associated cell to cell spread of intracellular bacterial pathogens
S Steele, L Radlinski, S Taft-Benz, J Brunton… - Elife, 2016 - elifesciences.org
Macrophages are myeloid-derived phagocytic cells and one of the first immune cell types to
respond to microbial infections. However, a number of bacterial pathogens are resistant to …
respond to microbial infections. However, a number of bacterial pathogens are resistant to …
Francisella tularensis inhibits the intrinsic and extrinsic pathways to delay constitutive apoptosis and prolong human neutrophil lifespan
JT Schwartz, JH Barker, J Kaufman… - The Journal of …, 2012 - journals.aai.org
Francisella tularensis is a facultative intracellular bacterium that infects many cell types,
including neutrophils. We demonstrated previously that F. tularensis inhibits NADPH …
including neutrophils. We demonstrated previously that F. tularensis inhibits NADPH …
Biofilms: An advancement in our understanding of Francisella species
ML Van Hoek - Virulence, 2013 - Taylor & Francis
Our understanding of the virulence and pathogenesis of Francisella spp. has significantly
advanced in recent years, including a new understanding that this organism can form …
advanced in recent years, including a new understanding that this organism can form …