Transforming growth factor-β in myocardial disease
NG Frangogiannis - Nature Reviews Cardiology, 2022 - nature.com
Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …
diseases and have an important role in cardiac repair and remodelling, regulating the …
Oxidative stress in cardiac hypertrophy: From molecular mechanisms to novel therapeutic targets
CJA Ramachandra, S Cong, X Chan, EP Yap… - Free Radical Biology …, 2021 - Elsevier
When faced with increased workload the heart undergoes remodelling, where it increases
its muscle mass in an attempt to preserve normal function. This is referred to as cardiac …
its muscle mass in an attempt to preserve normal function. This is referred to as cardiac …
Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
Progress in precision medicine is limited by insufficient knowledge of transcriptomic or
proteomic features in involved tissues that define pathobiological differences between …
proteomic features in involved tissues that define pathobiological differences between …
MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling
G Li, Y Shao, HC Guo, Y Zhi, B Qiao, K Ma… - Cardiovascular …, 2022 - academic.oup.com
Aims The heart undergoes pathological remodelling under increased stress and neuronal
imbalance. MicroRNAs (miRNAs) are involved in post-transcriptional regulation of genes in …
imbalance. MicroRNAs (miRNAs) are involved in post-transcriptional regulation of genes in …
The microRNA-29 family: role in metabolism and metabolic disease
LT Dalgaard, AE Sørensen… - American Journal of …, 2022 - journals.physiology.org
The microRNA-29 family members miR-29a-3p, miR-29b-3p, and miR-29c-3p are
ubiquitously expressed and consistently increased in various tissues and cell types in …
ubiquitously expressed and consistently increased in various tissues and cell types in …
Marked up-regulation of ACE2 in hearts of patients with obstructive hypertrophic cardiomyopathy: implications for SARS-CoV-2–mediated COVID-19
Objective To explore the transcriptomic differences between patients with hypertrophic
cardiomyopathy (HCM) and controls. Patients and Methods RNA was extracted from cardiac …
cardiomyopathy (HCM) and controls. Patients and Methods RNA was extracted from cardiac …
ACE2 Nascence, trafficking, and SARS-CoV-2 pathogenesis: the saga continues
With the emergence of the novel coronavirus SARS-CoV-2 since December 2019, more
than 65 million cases have been reported worldwide. This virus has shown high infectivity …
than 65 million cases have been reported worldwide. This virus has shown high infectivity …
Multi-omic architecture of obstructive hypertrophic cardiomyopathy
R Garmany, JM Bos, DJ Tester… - Circulation: Genomic …, 2023 - Am Heart Assoc
Background: Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left
ventricular hypertrophy. Currently, hypertrophy pathways responsible for HCM have not …
ventricular hypertrophy. Currently, hypertrophy pathways responsible for HCM have not …
A systematic review of microRNAs in patients with hypertrophic cardiomyopathy
FL Scolari, LS Faganello, HI Garbin, BP e Mattos… - International journal of …, 2021 - Elsevier
Abstract Background Several microRNAs (miRNA) have been associated with hypertrophic
cardiomyopathy (HCM), but studies differ regarding methods employed. In an attempt to …
cardiomyopathy (HCM), but studies differ regarding methods employed. In an attempt to …
MicroRNAs in hypertrophic, arrhythmogenic and dilated cardiomyopathy
E Chiti, M Di Paolo, E Turillazzi, A Rocchi - Diagnostics, 2021 - mdpi.com
MicroRNAs (miRNAs) are a class of non-coding RNAs of about 20 nucleotides in length,
involved in the regulation of many biochemical pathways in the human body. The level of …
involved in the regulation of many biochemical pathways in the human body. The level of …