The molecular hybridization approach has been used to develop compounds with improved
efficacy by combining two or more pharmacophores of bioactive scaffolds. In this context …

Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that
regulates many cellular processes. Given the central role of PP2A in regulating diverse …

Antibiotics are essential medications for human and animal health, as they are used to battle
urinary infections and bacterial diseases. Therefore, the rapid determination of antibiotic …

Phenothiazines have been used in many areas of medicine, mainly in psychopharmacology.
These compounds are able to effectively inhibit dopamine, histamine, serotonin …

The quinoline molecule is a chemical motif showing a highly promising pharmacological
potential. Its numerous derivatives introduced into medicine revolutionized in the treatment …

Phenothiazines (PTZs) have been used for the antipsychotic drugs for centuries. However,
some of these PTZs have been reported to exhibit antitumor effects by targeting various …

A dopamine receptor antagonist, Thioridazine (TDZ) is known for its cytotoxic activity against
various cancers and its role in combinational chemotherapy is being actively investigated …

Herein, we disclose a novel self-catalytic photochemical sulfonylation of phenothiazines, in
which phenothiazine functions as both a substrate and a photosensitizer. The reaction …

Background Angularly condensed diquinothiazines (MY1, MY2, and MY3) a phenothiazine
derivative was evaluated for antioxidant, antiglycation, sugar hydrolysis enzyme inhibitory …

A broad series of electronically diverse N-aryl substituted phenothiazines was readily
synthesized by Buchwald–Hartwig amination of 10H-phenothiazine and aryl bromides with …