Fabry disease is generally considered to be the second most prevalent lysosomal storage
disorder, after Gaucher disease, with an estimated incidence ranging between 1: 40,000 …

Fabry disease (FD) is a lysosomal storage disorder due to the impaired activity of the α-
galactosidase A (GLA) enzyme which induces Gb3 deposition and multiorgan dysfunction …

Current therapies for Fabry disease are based on reversing intracellular accumulation of
globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated …

Background Fabry disease (FD) is an X-linked lysosomal storage disorder characterized by
the progressive accumulation of globotriaosylceramide (Gb3) leading to systemic …

Fabry disease (FD) is an X-linked lysosomal storage disorder (LSD) secondary to mutations
in the GLA gene that causes dysfunctional activity of lysosomal hydrolase α-galactosidase A …

It is well established that lysosomal glucocerebrosidase gene (GBA) variants are a risk factor
for Parkinson's disease (PD), with increasing evidence suggesting a loss of function …

X‐linked parkinsonism encompasses rare heterogeneous disorders mainly inherited as a
recessive trait, therefore being more prevalent in males. Recent developments have …

Background. An increased prevalence of Parkinson's disease (PD) disease has been
previously reported in subjects with Fabry disease (FD) carrying alpha‐galactosidase (GLA) …

Anderson–Fabry disease (AFD) is an inherited lysosomal storage disorder characterized by
a composite and multisystemic clinical phenotype and frequent involvement of the central …

Although Gaucher disease can be accompanied by Lewy pathology (LP) and
extrapyramidal symptoms, it is unknown if LP exists in Fabry disease (FD), another …