Calcium and excitation-contraction coupling in the heart
Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …
Inherited Dysfunction of Sarcoplasmic Reticulum Ca2+ Handling and Arrhythmogenesis
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …
Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial …
Background—Delayed afterdepolarizations (DADs) carried by Na+-Ca2+-exchange current
(INCX) in response to sarcoplasmic reticulum (SR) Ca2+ leak can promote atrial fibrillation …
(INCX) in response to sarcoplasmic reticulum (SR) Ca2+ leak can promote atrial fibrillation …
[图书][B] Excitation-contraction coupling and cardiac contractile force
D Bers - 2001 - books.google.com
How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …
What are the links between cardiac structure and function? How does our understanding of …
The control of diastolic calcium in the heart: basic mechanisms and functional implications
Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …
Calcium in the pathophysiology of atrial fibrillation and heart failure
NC Denham, CM Pearman, JL Caldwell… - Frontiers in …, 2018 - frontiersin.org
Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …
exists between the two—AF exacerbates heart failure causing a significant increase in heart …
Enhanced Store Overload–Induced Ca2+ Release and Channel Sensitivity to Luminal Ca2+ Activation Are Common Defects of RyR2 Mutations Linked to Ventricular …
D Jiang, R Wang, B Xiao, H Kong, DJ Hunt… - Circulation …, 2005 - Am Heart Assoc
Ventricular tachycardia (VT) is the leading cause of sudden death, and the cardiac
ryanodine receptor (RyR2) is emerging as an important focus in its pathogenesis. RyR2 …
ryanodine receptor (RyR2) is emerging as an important focus in its pathogenesis. RyR2 …
The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias
Spontaneous Ca2+ release from intracellular stores is important for various physiological
and pathological processes. In cardiac muscle cells, spontaneous store overload–induced …
and pathological processes. In cardiac muscle cells, spontaneous store overload–induced …
Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternans
The aim of this work was to investigate whether beat-to-beat alternation in the amplitude of
the systolic Ca2+ transient (Ca2+ alternans) is due to changes of sarcoplasmic reticulum …
the systolic Ca2+ transient (Ca2+ alternans) is due to changes of sarcoplasmic reticulum …
Intracellular Na+ regulation in cardiac myocytes
DM Bers, WH Barry, S Despa - Cardiovascular research, 2003 - academic.oup.com
Abstract Intracellular [Na+]([Na+] i) is regulated in cardiac myocytes by a balance of Na+
influx and efflux mechanisms. In the normal cell there is a large steady state electrochemical …
influx and efflux mechanisms. In the normal cell there is a large steady state electrochemical …