Pathological implication of protein post-translational modifications in cancer
S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …
RAS isoforms and mutations in cancer at a glance
ABSTRACT RAS proteins (KRAS4A, KRAS4B, NRAS and HRAS) function as GDP–GTP-
regulated binary on-off switches, which regulate cytoplasmic signaling networks that control …
regulated binary on-off switches, which regulate cytoplasmic signaling networks that control …
[HTML][HTML] The current understanding of KRAS protein structure and dynamics
T Pantsar - Computational and structural biotechnology journal, 2020 - Elsevier
One of the most common drivers in human cancer is the mutant KRAS protein. Not so long
ago KRAS was considered as an undruggable oncoprotein. After a long struggle, however …
ago KRAS was considered as an undruggable oncoprotein. After a long struggle, however …
KRAS alleles: the devil is in the detail
KM Haigis - Trends in cancer, 2017 - cell.com
KRAS is the most frequently mutated oncogene in cancer and KRAS mutation is commonly
associated with poor prognosis and resistance to therapy. Since the KRAS oncoprotein is …
associated with poor prognosis and resistance to therapy. Since the KRAS oncoprotein is …
RAS: Striking at the Core of the Oncogenic Circuitry
Cancer is a devastating disease process that touches the lives of millions worldwide.
Despite advances in our understanding of the genomic architecture of cancers and the …
Despite advances in our understanding of the genomic architecture of cancers and the …
Ras conformational ensembles, allostery, and signaling
Ras proteins are classical members of small GTPases that function as molecular switches by
alternating between inactive GDP-bound and active GTP-bound states. Ras activation is …
alternating between inactive GDP-bound and active GTP-bound states. Ras activation is …
Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention
C Johnson, DL Burkhart, KM Haigis - Cancer discovery, 2022 - AACR
Members of the family of RAS proto-oncogenes, discovered just over 40 years ago, were
among the first cancer-initiating genes to be discovered. Of the three RAS family members …
among the first cancer-initiating genes to be discovered. Of the three RAS family members …
RAS mutations in human cancers: Roles in precision medicine
AK Murugan, M Grieco, N Tsuchida - Seminars in cancer biology, 2019 - Elsevier
Ras proteins play a crucial role as a central component of the cellular networks controlling a
variety of signaling pathways that regulate growth, proliferation, survival, differentiation …
variety of signaling pathways that regulate growth, proliferation, survival, differentiation …
[HTML][HTML] Therapeutic targeting of RAS: New hope for drugging the “undruggable”
I Khan, JM Rhett, JP O'Bryan - … et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
RAS is the most frequently mutated oncogene in cancer and a critical driver of oncogenesis.
Therapeutic targeting of RAS has been a goal of cancer research for more than 30 years …
Therapeutic targeting of RAS has been a goal of cancer research for more than 30 years …
[HTML][HTML] Stopping the beating heart of cancer: KRAS reviewed
L Herdeis, D Gerlach, DB McConnell… - Current opinion in …, 2021 - Elsevier
It has taken four decades of research to see the first major breakthrough for KRAS-driven
cancers. In particular, the last decade has seen a paradigm shift with the discovery of …
cancers. In particular, the last decade has seen a paradigm shift with the discovery of …