Ribosome biogenesis in cancer: new players and therapeutic avenues
J Pelletier, G Thomas, S Volarević - Nature Reviews Cancer, 2018 - nature.com
The ribosome is a complex molecular machine composed of numerous distinct proteins and
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …
nucleic acids and is responsible for protein synthesis in every living cell. Ribosome …
Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes
One of the first biological machineries to be created seems to have been the ribosome.
Since then, organisms have dedicated great efforts to optimize this apparatus. The …
Since then, organisms have dedicated great efforts to optimize this apparatus. The …
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization
D Dilworth, RP Hanley, R Ferreira de Freitas… - Nature chemical …, 2022 - nature.com
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme
responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with …
responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with …
Sirtuins in epigenetic regulation
1.1. Discovery of Sirtuins The founding member of sirtuin is the yeast-silencing information
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …
regulator 2 (SIR2) protein, one of four proteins (SIR1− 4) required for silencing the mating …
'View from a bridge': a new perspective on eukaryotic rRNA base modification
S Sharma, DLJ Lafontaine - Trends in biochemical sciences, 2015 - cell.com
Eukaryotic rRNA are modified frequently, although the diversity of modifications is low: in
yeast rRNA, there are only 12 different types out of a possible natural repertoire exceeding …
yeast rRNA, there are only 12 different types out of a possible natural repertoire exceeding …
Biomarkers associated with low, moderate, and high vastus lateralis muscle hypertrophy following 12 weeks of resistance training
We sought to identify biomarkers which delineated individual hypertrophic responses to
resistance training. Untrained, college-aged males engaged in full-body resistance training …
resistance training. Untrained, college-aged males engaged in full-body resistance training …
SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation
R Vendramin, Y Verheyden, H Ishikawa… - Nature structural & …, 2018 - nature.com
Synchronization of mitochondrial and cytoplasmic translation rates is critical for the
maintenance of cellular fitness, with cancer cells being especially vulnerable to translational …
maintenance of cellular fitness, with cancer cells being especially vulnerable to translational …
Regulation of RNA polymerase I transcription in development, disease, and aging
S Sharifi, H Bierhoff - Annual review of biochemistry, 2018 - annualreviews.org
Ribosome biogenesis is a complex and highly energy-demanding process that requires the
concerted action of all three nuclear RNA polymerases (Pol I–III) in eukaryotes. The three …
concerted action of all three nuclear RNA polymerases (Pol I–III) in eukaryotes. The three …
Nucleolus and chromatin
C Schöfer, K Weipoltshammer - Histochemistry and cell biology, 2018 - Springer
The nucleolus as site of ribosome biogenesis holds a pivotal role in cell metabolism. It is
composed of ribosomal DNA (rDNA), which is present as tandem arrays located in nucleolus …
composed of ribosomal DNA (rDNA), which is present as tandem arrays located in nucleolus …
Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress
X Liu, S Cai, C Zhang, Z Liu, J Luo, B Xing… - Nucleic acids …, 2018 - academic.oup.com
Anabolism and catabolism are tightly regulated according to the cellular energy supply.
Upon energy stress, ribosomal RNA (rRNA) biogenesis is inhibited, and autophagy is …
Upon energy stress, ribosomal RNA (rRNA) biogenesis is inhibited, and autophagy is …