Over the last several decades, it has become clear that epigenetic abnormalities may be one
of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Epigenetic enzymes are often dysregulated in human tumors through mutation, altered
expression, or inappropriate recruitment to certain loci. The identification of these enzymes …

Cells possess an armamentarium of DNA repair pathways to counter DNA damage and
prevent mutation. Here we use C. elegans whole genome sequencing to systematically …

Cancer initiation and progression are the result of genetic and/or epigenetic alterations.
Acetylation-mediated histone/non-histone protein modification plays an important role in the …

Reversible acetylation of histone and non-histone proteins is one of the most abundant post-
translational modifications in eukaryotic cells. Protein acetylation and deacetylation are …

Histone deacetylases comprise a family of 18 genes, which are grouped into classes I–IV
based on their homology to their respective yeast orthologues. Classes I, II, and IV consist of …

Protein lysine deacetylases have a pivotal role in numerous biological processes and can
be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse …

HDACs (histone deacetylases) 1 and 2 are ubiquitous long-lived proteins, which are often
found together in three major multiprotein co-repressor complexes: Sin3, NuRD …

Transcription regulation through chromatin compaction and decompaction is regulated
through various chromatin-remodeling complexes such as nucleosome remodeling and …