Networking brainstem and basal ganglia circuits for movement

S Arber, RM Costa - Nature Reviews Neuroscience, 2022 - nature.com
The execution and learning of diverse movements involve neuronal networks distributed
throughout the nervous system. The brainstem and basal ganglia are key for processing …

Quantifying behavior to understand the brain

TD Pereira, JW Shaevitz, M Murthy - Nature neuroscience, 2020 - nature.com
Over the past years, numerous methods have emerged to automate the quantification of
animal behavior at a resolution not previously imaginable. This has opened up a new field of …

Spontaneous behaviour is structured by reinforcement without explicit reward

JE Markowitz, WF Gillis, M Jay, J Wood, RW Harris… - Nature, 2023 - nature.com
Spontaneous animal behaviour is built from action modules that are concatenated by the
brain into sequences,. However, the neural mechanisms that guide the composition of …

Negative feedback control of neuronal activity by microglia

A Badimon, HJ Strasburger, P Ayata, X Chen, A Nair… - Nature, 2020 - nature.com
Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …

Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons

S Yun, B Yang, JD Anair, MM Martin, SW Fleps… - Nature …, 2023 - nature.com
Elevated dopamine transmission in psychosis is assumed to unbalance striatal output
through D1-and D2-receptor-expressing spiny-projection neurons (SPNs). Antipsychotic …

Striatal circuits for reward learning and decision-making

J Cox, IB Witten - Nature Reviews Neuroscience, 2019 - nature.com
The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …

Revealing the structure of pharmacobehavioral space through motion sequencing

AB Wiltschko, T Tsukahara, A Zeine, R Anyoha… - Nature …, 2020 - nature.com
Understanding how genes, drugs and neural circuits influence behavior requires the ability
to effectively organize information about similarities and differences within complex …

Circuit mechanisms of Parkinson's disease

MM McGregor, AB Nelson - Neuron, 2019 - cell.com
Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …

Computational neuroethology: a call to action

SR Datta, DJ Anderson, K Branson, P Perona, A Leifer - Neuron, 2019 - cell.com
The brain is worthy of study because it is in charge of behavior. A flurry of recent technical
advances in measuring and quantifying naturalistic behaviors provide an important …

Dopamine neuron activity before action initiation gates and invigorates future movements

JA Da Silva, F Tecuapetla, V Paixão, RM Costa - Nature, 2018 - nature.com
Deciding when and whether to move is critical for survival. Loss of dopamine neurons
(DANs) of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease …