Networking brainstem and basal ganglia circuits for movement
S Arber, RM Costa - Nature Reviews Neuroscience, 2022 - nature.com
The execution and learning of diverse movements involve neuronal networks distributed
throughout the nervous system. The brainstem and basal ganglia are key for processing …
throughout the nervous system. The brainstem and basal ganglia are key for processing …
Quantifying behavior to understand the brain
Over the past years, numerous methods have emerged to automate the quantification of
animal behavior at a resolution not previously imaginable. This has opened up a new field of …
animal behavior at a resolution not previously imaginable. This has opened up a new field of …
Spontaneous behaviour is structured by reinforcement without explicit reward
Spontaneous animal behaviour is built from action modules that are concatenated by the
brain into sequences,. However, the neural mechanisms that guide the composition of …
brain into sequences,. However, the neural mechanisms that guide the composition of …
Negative feedback control of neuronal activity by microglia
Microglia, the brain's resident macrophages, help to regulate brain function by removing
dying neurons, pruning non-functional synapses, and producing ligands that support …
dying neurons, pruning non-functional synapses, and producing ligands that support …
Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons
Elevated dopamine transmission in psychosis is assumed to unbalance striatal output
through D1-and D2-receptor-expressing spiny-projection neurons (SPNs). Antipsychotic …
through D1-and D2-receptor-expressing spiny-projection neurons (SPNs). Antipsychotic …
Striatal circuits for reward learning and decision-making
The striatum is essential for learning which actions lead to reward and for implementing
those actions. Decades of experimental and theoretical work have led to several influential …
those actions. Decades of experimental and theoretical work have led to several influential …
Revealing the structure of pharmacobehavioral space through motion sequencing
Understanding how genes, drugs and neural circuits influence behavior requires the ability
to effectively organize information about similarities and differences within complex …
to effectively organize information about similarities and differences within complex …
Circuit mechanisms of Parkinson's disease
MM McGregor, AB Nelson - Neuron, 2019 - cell.com
Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The
second most common neurodegenerative disorder after Alzheimer's disease, it affects …
second most common neurodegenerative disorder after Alzheimer's disease, it affects …
Computational neuroethology: a call to action
The brain is worthy of study because it is in charge of behavior. A flurry of recent technical
advances in measuring and quantifying naturalistic behaviors provide an important …
advances in measuring and quantifying naturalistic behaviors provide an important …
Dopamine neuron activity before action initiation gates and invigorates future movements
Deciding when and whether to move is critical for survival. Loss of dopamine neurons
(DANs) of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease …
(DANs) of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease …