Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases
CR Harrell, N Jovicic, V Djonov, N Arsenijevic… - Cells, 2019 - mdpi.com
There is growing evidence that mesenchymal stem cell (MSC)-based immunosuppression
was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC …
was mainly attributed to the effects of MSC-derived extracellular vesicles (MSC-EVs). MSC …
Impact of cryopreservation and freeze-thawing on therapeutic properties of mesenchymal stromal/stem cells and other common cellular therapeutics
C Cottle, AP Porter, A Lipat, C Turner-Lyles… - Current stem cell …, 2022 - Springer
Abstract Purpose of Review Cryopreservation and its associated freezing and thawing
procedures–short “freeze-thawing”–are among the final steps in economically viable …
procedures–short “freeze-thawing”–are among the final steps in economically viable …
Mesenchymal stromal cell apoptosis is required for their therapeutic function
Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in
preclinical models, but the lack of clarity around their mechanisms of action has impeded …
preclinical models, but the lack of clarity around their mechanisms of action has impeded …
Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes
C Zheng, B Sui, X Zhang, J Hu, J Chen… - Journal of …, 2021 - Wiley Online Library
Apoptosis is a naturally occurring process generating plenty of apoptotic vesicles (apoVs),
but the feature, fate and function of apoVs remain largely unknown. Notably, as an …
but the feature, fate and function of apoVs remain largely unknown. Notably, as an …
The therapeutic potential of mesenchymal stromal cells for regenerative medicine: current knowledge and future understandings
M Merimi, R El-Majzoub, L Lagneaux… - Frontiers in Cell and …, 2021 - frontiersin.org
In recent decades, research on the therapeutic potential of progenitor cells has advanced
considerably. Among progenitor cells, mesenchymal stromal cells (MSCs) have attracted …
considerably. Among progenitor cells, mesenchymal stromal cells (MSCs) have attracted …
The current status of mesenchymal stromal cells: controversies, unresolved issues and some promising solutions to improve their therapeutic efficacy
D García-Bernal, M García-Arranz… - Frontiers in Cell and …, 2021 - frontiersin.org
Mesenchymal stromal cells (MSCs) currently constitute the most frequently used cell type in
advanced therapies with different purposes, most of which are related with inflammatory …
advanced therapies with different purposes, most of which are related with inflammatory …
Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells
Considering the unique therapeutic potential of mesenchymal stem cells (MSCs), including
their immunosuppressive and immunomodulatory properties as well as their ability to …
their immunosuppressive and immunomodulatory properties as well as their ability to …
Mesenchymal stem cell-derived extracellular vesicles for the treatment of acute respiratory distress syndrome
A Abraham, A Krasnodembskaya - Stem Cells Translational …, 2020 - academic.oup.com
Acute respiratory distress syndrome (ARDS) is a serious and potentially fatal acute
inflammatory lung condition which currently has no specific treatments targeting its …
inflammatory lung condition which currently has no specific treatments targeting its …
CCL2 and CXCL12 derived from mesenchymal stromal cells cooperatively polarize IL-10+ tissue macrophages to mitigate gut injury
Mesenchymal stromal cell (MSC)-based therapy for inflammatory diseases involves
paracrine and efferocytotic activation of immunosuppressive interleukin-10+(IL-10+) …
paracrine and efferocytotic activation of immunosuppressive interleukin-10+(IL-10+) …
Proteomic analysis of MSC‐derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a via activating platelet functions
X Zhang, J Tang, X Kou, W Huang… - Journal of …, 2022 - Wiley Online Library
Apoptotic vesicles (apoVs) are apoptotic cell‐derived nanosized vesicles that play a crucial
role in multiple pathophysiological settings. However, their detailed characteristics, specific …
role in multiple pathophysiological settings. However, their detailed characteristics, specific …