Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung
carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts …

DNA damage plays a major role in various pathophysiological conditions including
carcinogenesis, aging, inflammation, diabetes and neurodegenerative diseases. Oxidative …

Chronic inflammation has been recognized as a contributing factor in the pathogenesis of
lung cancer. In this process, reactive oxygen species released by neutrophils may play an …

Accumulating evidence suggests that oxidation-specific epitopes (OSEs) constitute a novel
class of damage-associated molecular patterns (DAMPs) generated during high oxidative …

Background Although lung cancer is among the few malignancies for which we know the
primary etiological agent (ie, cigarette smoke), a precise understanding of the temporal …

Tobacco smoke contains a variety of genotoxic carcinogens that form adducts with DNA and
protein in the tissues of smokers. Not only are these biochemical events relevant to the …

Disturbed redox status may be critical to lung cancerogenesis, however little research has
been conducted on general changes in total redox status in lung cancer. Levels and …

Aim: To study the effect of silymarin on the levels of tumor markers and MDA
(malondialdehyde)–DNA adduct formation during N-nitrosodiethylamine induced …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic, lethal disease of which the
etiology is still not fully understood. Current treatment comprises two FDA-approved drugs …

This review summarizes the carcinogenic effects of tobacco smoke and the basis for
interaction between tobacco smoke and genetic factors. Examples of published papers on …