The pentose phosphate pathway in health and disease
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
Glutathione metabolism in plants under stress: beyond reactive oxygen species detoxification
S Dorion, JC Ouellet, J Rivoal - Metabolites, 2021 - mdpi.com
Glutathione is an essential metabolite for plant life best known for its role in the control of
reactive oxygen species (ROS). Glutathione is also involved in the detoxification of …
reactive oxygen species (ROS). Glutathione is also involved in the detoxification of …
Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils
Neutrophils are cells at the frontline of innate immunity that can quickly activate effector
functions to eliminate pathogens upon stimulation. However, little is known about the …
functions to eliminate pathogens upon stimulation. However, little is known about the …
The GAPDH redox switch safeguards reductive capacity and enables survival of stressed tumour cells
D Talwar, CG Miller, J Grossmann, L Szyrwiel… - Nature …, 2023 - nature.com
Abstract Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known to contain an
active-site cysteine residue undergoing oxidation in response to hydrogen peroxide, leading …
active-site cysteine residue undergoing oxidation in response to hydrogen peroxide, leading …
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations
and are often refractory to approved targeted therapies. We found that cultured human CRC …
and are often refractory to approved targeted therapies. We found that cultured human CRC …
TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging
P Davizon-Castillo, B McMahon… - Blood, The Journal …, 2019 - ashpublications.org
Aging and chronic inflammation are independent risk factors for the development of
atherothrombosis and cardiovascular disease. We hypothesized that aging-associated …
atherothrombosis and cardiovascular disease. We hypothesized that aging-associated …
Four key steps control glycolytic flux in mammalian cells
Altered glycolysis is a hallmark of diseases including diabetes and cancer. Despite intensive
study of the contributions of individual glycolytic enzymes, systems-level analyses of flux …
study of the contributions of individual glycolytic enzymes, systems-level analyses of flux …
Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
In metabolism, available free energy is limited and must be divided across pathway steps to
maintain a negative Δ G throughout. For each reaction, Δ G is log proportional both to a …
maintain a negative Δ G throughout. For each reaction, Δ G is log proportional both to a …
Molecular mechanisms behind free radical scavengers function against oxidative stress
F Ahmadinejad, S Geir Møller… - Antioxidants, 2017 - mdpi.com
Accumulating evidence shows that oxidative stress is involved in a wide variety of human
diseases: rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, cancers, etc. Here …
diseases: rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, cancers, etc. Here …
Acute activation of oxidative pentose phosphate pathway as first-line response to oxidative stress in human skin cells
Integrity of human skin is endangered by exposure to UV irradiation and chemical stressors,
which can provoke a toxic production of reactive oxygen species (ROS) and oxidative …
which can provoke a toxic production of reactive oxygen species (ROS) and oxidative …