The complex bidirectional communication between the gut and the brain is finely
orchestrated by different systems, including the endocrine, immune, autonomic, and enteric …

Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role
in the pathogenesis of inflammatory bowel disease (IBD). The brain-gut axis involves …

The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …

Psychological stress has long been reported anecdotally to increase disease activity in
inflammatory bowel disease (IBD), and recent well designed studies have confirmed that …

BACKGROUND & AIMS: Stress alters brain–gut interactions and could exacerbate intestinal
disorders, including irritable bowel syndrome. Alterations in the intestinal microbiota have …

OBJECTIVES: Low-grade colonic mucosal inflammation has been postulated to have an
important role in the pathophysiology of irritable bowel syndrome (IBS). The objectives of …

It is well established that central corticotropin releasing factor (CRF) signaling mediates the
gastrointestinal responses to stress. However, as shown in the brain, both CRF receptors …

Inflammatory bowel disease (IBD) is a chronic, relapsing condition involving complex
interactions between genes and the environment. The mechanisms triggering the initial …

Background and aims: Psychological stress plays an important role in an array of intestinal
disorders. Corticotrophin releasing hormone (CRH) is involved in the pathogenic process …

There are well-replicated, independent lines of evidence supporting a role for corticotropin-
releasing hormone (CRH) in the pathophysiology of depression. CRH receptor 1 (CRHR1) …