Ferulic acid: a hope for Alzheimer's disease therapy from plants

A Sgarbossa, D Giacomazza, M Di Carlo - Nutrients, 2015 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the deposition of
extracellular amyloid-beta peptide (Aβ) and intracellular neurofibrillar tangles, associated …

Targeting amyloid aggregation: an overview of strategies and mechanisms

S Giorgetti, C Greco, P Tortora, FA Aprile - International journal of …, 2018 - mdpi.com
Amyloids result from the aggregation of a set of diverse proteins, due to either specific
mutations or promoting intra-or extra-cellular conditions. Structurally, they are rich in …

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

M Tardivel, S Bégard, L Bousset, S Dujardin… - Acta neuropathologica …, 2016 - Springer
A given cell makes exchanges with its neighbors through a variety of means ranging from
diffusible factors to vesicles. Cells use also tunneling nanotubes (TNTs), filamentous-actin …

Common mechanisms underlying α-synuclein-induced mitochondrial dysfunction in Parkinson's disease

T Sohrabi, B Mirzaei-Behbahani, R Zadali… - Journal of Molecular …, 2023 - Elsevier
Parkinson's disease (PD) is the most common neurological movement disorder
characterized by the selective and irreversible loss of dopaminergic neurons in substantia …

Protein folding and aggregation into amyloid: the interference by natural phenolic compounds

M Stefani, S Rigacci - International journal of molecular sciences, 2013 - mdpi.com
Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …

Toxic mechanism and biological detoxification of fumonisins

L Qu, L Wang, H Ji, Y Fang, P Lei, X Zhang, L Jin… - Toxins, 2022 - mdpi.com
Food safety is related to the national economy and people's livelihood. Fumonisins are
widely found in animal feed, feed raw materials, and human food. This can not only cause …

Role of different alpha-synuclein strains in synucleinopathies, similarities with other neurodegenerative diseases

R Melki - Journal of Parkinson's disease, 2015 - content.iospress.com
Misfolded protein aggregates are the hallmark of several neurodegenerative diseases in
humans. The main protein constituent of these aggregates and the regions within the brain …

Direct three-dimensional visualization of membrane disruption by amyloid fibrils

L Milanesi, T Sheynis, WF Xue… - Proceedings of the …, 2012 - National Acad Sciences
Protein misfolding and aggregation cause serious degenerative conditions such as
Alzheimer's, Parkinson, and prion diseases. Damage to membranes is thought to be one of …

Structural features and cytotoxicity of amyloid oligomers: implications in Alzheimer's disease and other diseases with amyloid deposits

M Stefani - Progress in neurobiology, 2012 - Elsevier
Amyloid diseases display the presence, in targeted tissues and organs, of fibrillar deposits of
specific peptides or proteins. Increasing efforts are presently spent in investigating the …

Potential role of natural polyphenols against protein aggregation toxicity: in vitro, in vivo, and clinical studies

G Henríquez, A Gomez, E Guerrero… - ACS Chemical …, 2020 - ACS Publications
One of the main features of neurodegenerative disorders such as Alzheimer's disease and
Parkinson's disease is the amyloidogenic behavior of disease-specific proteins including …