Introduction: There is a growing body of evidence to suggest that chronic silent inflammation
is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and …

Chronic kidney disease (CKD) is becoming a worldwide epidemic, driven largely by the
dramatic rise in the prevalence of diabetes and obesity. Novel targets and treatments for …

Accumulating evidences showed metformin and berberine, well‐known glucose‐lowering
agents, were able to inhibit mitochondrial electron transport chain at complex I. In this study …

The concept that excess superoxide production from mitochondria is the driving, initial
cellular response underlying diabetes complications has been held for the past decade …

Adenosine 5′-monophosphate activated protein kinase (AMPK) is a key enzymatic protein
involved in linking the energy sensing to the metabolic manipulation. It is a serine/threonine …

Berberine is a plant alkaloid with anti-diabetic action. Activation of AMP-activated protein
kinase (AMPK) pathway has been proposed as mechanism for berberine's action. This study …

The circadian clock is a master regulator in coordinating daily oscillations of physiology and
behaviors. Nevertheless, how the circadian rhythm affects endochondral ossification is …

Chronic pain is a major clinical problem that is poorly treated with available therapeutics.
Adenosine monophosphate-activated protein kinase (AMPK) has recently emerged as a …

Several epidemiologic studies have revealed strong inverse associations between
metformin use and risk of colorectal cancer development. Nevertheless, the underlying …

Background AMP-activated protein kinase (AMPK) is an effective target for treating diabetes.
However, successful drug development is delayed due to issues including toxicity. Plant …