[HTML][HTML] Allosteric modulation of GPCRs: new insights and potential utility for treatment of schizophrenia and other CNS disorders
G-protein-coupled receptors (GPCRs) play critical roles in regulating brain function. Recent
advances have greatly expanded our understanding of these receptors as complex …
advances have greatly expanded our understanding of these receptors as complex …
Large-scale functional connectivity networks in the rodent brain
A Gozzi, AJ Schwarz - Neuroimage, 2016 - Elsevier
Abstract Resting-state functional Magnetic Resonance Imaging (rsfMRI) of the human brain
has revealed multiple large-scale neural networks within a hierarchical and complex …
has revealed multiple large-scale neural networks within a hierarchical and complex …
Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo …
JH Krystal, JM Kane, CU Correll, DP Walling, M Leoni… - The Lancet, 2022 - thelancet.com
Background Emraclidine is a novel, brain-penetrant, highly selective M4 receptor positive
allosteric modulator in development for the treatment of schizophrenia. We aimed to …
allosteric modulator in development for the treatment of schizophrenia. We aimed to …
Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
Novel allosteric modulators of G protein-coupled receptors (GPCRs) are providing
fundamental advances in the development of GPCR ligands with high subtype selectivity …
fundamental advances in the development of GPCR ligands with high subtype selectivity …
Targeting muscarinic acetylcholine receptors for the treatment of psychiatric and neurological disorders
Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex
behaviors such as cognition, movement, and reward, making them ideally situated as …
behaviors such as cognition, movement, and reward, making them ideally situated as …
Targeting muscarinic receptors to treat schizophrenia
Schizophrenia is a severe neuropsychiatric disorder characterized by a diverse range of
symptoms that can have profound impacts on the lives of patients. Currently available …
symptoms that can have profound impacts on the lives of patients. Currently available …
Antipsychotic-like effects of M4 positive allosteric modulators are mediated by CB2 receptor-dependent inhibition of dopamine release
DJ Foster, JM Wilson, DH Remke, MS Mahmood… - Neuron, 2016 - cell.com
Muscarinic receptors represent a promising therapeutic target for schizophrenia, but the
mechanisms underlying the antipsychotic efficacy of muscarinic modulators are not well …
mechanisms underlying the antipsychotic efficacy of muscarinic modulators are not well …
Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents
Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR)
represent a novel approach for the treatment of psychotic symptoms associated with …
represent a novel approach for the treatment of psychotic symptoms associated with …
Fine tuning muscarinic acetylcholine receptor signaling through allostery and bias
The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …
targets for neurological diseases, in particular for Alzheimer's disease and schizophrenia …
Cell-type-specific translation profiling reveals a novel strategy for treating fragile X syndrome
SR Thomson, SS Seo, SA Barnes, SR Louros… - Neuron, 2017 - cell.com
Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu
1/5) is a core pathophysiology of fragile X syndrome (FX); however, the differentially …
1/5) is a core pathophysiology of fragile X syndrome (FX); however, the differentially …