Mitochondria, the 'powerhouse'of eukaryotic cells, play a key role in cellular homeostasis.
However, defective mitochondria increase mitochondrial ROS (mtROS) production and cell …

Elucidating the molecular mechanisms of psychopathology is crucial for optimized diagnosis
and treatment. Accumulating literature has underlined how mitochondrial bioenergetics …

Various exercise-training types are known to prevent depression, but mechanisms
underlying their beneficial effects remain unknown. In the present study, the preconditioning …

Inflammation plays an important role in depression pathology, making it a promising target
for ameliorating depression-like behaviors. The peroxisome proliferator-activated receptor …

Esketamine provides an immediate and noticeable antidepressant effect, although the
underlying molecular processes are yet unclear. Irisin induced by aerobic exercise has been …

Tryptophan and kynurenine pathway (KP) metabolites are implicated in the pathophysiology
of depression. We aimed to investigate their plasma concentrations in medicated patients …

Depression is the most prevalent mental disorder, affecting more than 300 million adults
worldwide each year, which can lead to serious economic and social problems …

Abstract Headings ethnopharmacological relevance Anshen Dingzhi prescription (ADP),
which was first published in the masterpiece of traditional Chinese Medicine in the Qing …

Mitochondrial dysfunction is implicated in the pathophysiology of major depressive disorder
(MDD). This dysfunction can be indirectly assessed using the mitochondrial DNA (mtDNA) …

Decreased hippocampal synaptic plasticity is an important pathological change in stress-
related mood disorders, including major depressive disorder. However, the underlying …