Direct effects of thyroid hormones on hepatic lipid metabolism

RA Sinha, BK Singh, PM Yen - Nature Reviews Endocrinology, 2018 - nature.com
It has been known for a long time that thyroid hormones have prominent effects on hepatic
fatty acid and cholesterol synthesis and metabolism. Indeed, hypothyroidism has been …

[HTML][HTML] NAFLD and extra-hepatic comorbidities: current evidence on a multi-organ metabolic syndrome

V Rosato, M Masarone, M Dallio, A Federico… - International journal of …, 2019 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with …

Thyroid function and the risk of nonalcoholic fatty liver disease: the Rotterdam study

A Bano, L Chaker, EPC Plompen… - The Journal of …, 2016 - academic.oup.com
Context: Although thyroid function is associated with several risk factors of nonalcoholic fatty
liver disease (NAFLD), its role in NAFLD development remains unclear. Objective: We …

Subclinical hypothyroidism and low-normal thyroid function are associated with nonalcoholic steatohepatitis and fibrosis

D Kim, W Kim, SK Joo, JM Bae, JH Kim… - Clinical gastroenterology …, 2018 - Elsevier
Background & Aims Variations in level of thyroid-stimulating hormone (TSH) within the
reference range of thyroid hormone could have negative health effects. We evaluated the …

[HTML][HTML] Hypothyroidism-associated dyslipidemia: potential molecular mechanisms leading to NAFLD

M Mavromati, FR Jornayvaz - International Journal of Molecular Sciences, 2021 - mdpi.com
Thyroid hormones control lipid metabolism by exhibiting specific effects on the liver and
adipose tissue in a coordinated manner. Different diseases of the thyroid gland can result in …

Association of non-alcoholic fatty liver disease with thyroid function: A systematic review and meta-analysis

Z Guo, M Li, B Han, X Qi - Digestive and Liver Disease, 2018 - Elsevier
Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic
liver diseases. The relationship of NAFLD with thyroid function parameters and …

[HTML][HTML] Relationship between hypothyroidism and non-alcoholic fatty liver disease: a systematic review and meta-analysis

W He, X An, L Li, X Shao, Q Li, Q Yao… - Frontiers in …, 2017 - frontiersin.org
Background Previous studies propose that hypothyroidism might play a crucial role in the
pathogenesis of non-alcoholic fatty liver disease (NAFLD), but findings from published …

[HTML][HTML] Lean patients with non-alcoholic fatty liver disease have a severe histological phenotype similar to obese patients

L Denkmayr, A Feldman, L Stechemesser… - Journal of clinical …, 2018 - mdpi.com
A small proportion of lean patients develop non-alcoholic fatty liver disease (NAFLD). We
aimed to report the histological picture of lean NAFLD in comparison to overweight and …

[HTML][HTML] Thyroid dysfunction and dysmetabolic syndrome: the need for enhanced thyrovigilance strategies

S Kalra, S Aggarwal, D Khandelwal - International journal of …, 2021 - hindawi.com
Thyroid dysfunction (TD) is common in metabolic disorders such as diabetes mellitus (DM),
cardiovascular disease (CVD), obesity, dyslipidemia, hyperuricemia, kidney and liver …

Extrahepatic manifestations of nonalcoholic fatty liver disease

LB VanWagner, ME Rinella - Current hepatology reports, 2016 - Springer
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease
worldwide with an increased prevalence of metabolic, macro-, and microvascular …