Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional
groups to explore and understand biology in living organisms. In this review, we summarize …

In recent years, powerful genetic code reprogramming methods have emerged that allow
new functional components to be embedded into proteins as noncanonical amino acid …

The covalent immobilisation of enzymes generally involves the use of highly reactive
crosslinkers, such as glutaraldehyde, to couple enzyme molecules to each other or to …

We report a bioinformatic workflow and subsequent discovery of a new polyethylene
terephthalate (PET) hydrolase, which we named MG8, from the human saliva metagenome …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

Improvement in intrinsic enzymatic features is in many instances a prerequisite for the
scalable applicability of many industrially important biocatalysts. To this end, various …

The ability to selectively modify proteins at two or more defined locations opens new
avenues for manipulating, engineering, and studying living systems. As a chemical biology …

Surface modification techniques are crucial in biomedical applications as they determine the
direct response to the biological environment against the interfacing materials. Physical and …

Biomarkers play an important and irrefutable role in the screening, diagnosis, monitoring
and treatment of a wide variety of human diseases. As these biomarkers inevitably feature …

The intrinsic recalcitrance of lignocellulosic biomass makes it resistant to enzymatic
hydrolysis. The electron-rich surface of the lignin and cellulose-alike structure of …