Fibrosis is a pathological feature of most chronic inflammatory diseases. Fibrosis, or
scarring, is defined by the accumulation of excess extracellular matrix components. If highly …

Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or
damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction …

Myofibroblasts are non-muscle contractile cells that play a key physiologically role in organs
such as the stem villi of the human placenta during physiological pregnancy. They are able …

Different anatomic and physiological changes occur in the lung of aging people that can
affect pulmonary functions, and different pulmonary diseases, including deadly diseases …

Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …

Both COPD and lung cancer are major worldwide health concerns owing to cigarette
smoking, and represent a huge, worldwide, preventable disease burden. Whilst the majority …

Chronic lung diseases represent a major public health problem with only limited therapeutic
options. An important unmet need is to identify compounds and drugs that target key …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. One
main pathological feature of COPD is the loss of functional alveolar tissue without adequate …

Cancer is the second leading cause of death globally. Millions of persons die due to cancer
each year. In the last two decades, the anticancer effects of natural flavonoids have become …

Airway diseases such as chronic rhinosinusitis, asthma, and chronic obstructive pulmonary
disorder are characterized by inflammation and remodeling. Among inflammatory and …