During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …

Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

The number of the elderly across the globe will approximate 2.1 billion by 2050. Juxtaposed
against this burgeoning segment of the population is evidence that nonpathological aging is …

Alzheimer disease (AD) is the most common cause of dementia in people over 60 years old.
The molecular and cellular alterations that trigger this disease are still diffuse, one of the …

Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …

Neurogenesis, a process of generation of new neurons, is reported to be reduced in several
neurodegenerative disorders including Alzheimer's disease (AD). Induction of neurogenesis …

Adult neurogenesis, a complex process by which stem cells in the hippocampal brain region
differentiate and proliferate into new neurons and other resident brain cells, is known to be …

Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry
powder), has been used for centuries as a treatment for inflammatory diseases. Extensive …

This review summarizes and describes the use of curcumin in diagnosis, prevention, and
treatment of Alzheimer's disease. For diagnosis of Alzheimer's disease, amyloid-β and …