Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …

Decades of efforts in engineering in vitro cancer models have advanced drug discovery and
the insight into cancer biology. However, the establishment of preclinical models that enable …

Neovascularization, the formation of new blood vessels, has received much research
attention due to its implications for physiological processes and diseases. Most studies …

Head and neck squamous cell carcinoma (HNSCC) is among the most severe and complex
malignant diseases with a high level of heterogeneity and, as a result, a wide range of …

Simple Summary The extensive array of applications in 3D culture models closely mimics
the precise physiological conditions of in vivo settings, enabling the investigation of …

Regional metastasis of head and neck cancer (HNC) is prevalent (approximately 50% of
patients at diagnosis), yet the underlying drivers and mechanisms of lymphatic spread …

For over a decade, we have seen significant strides in the microfluidics field that have led to
the concept of microphysiological systems. These systems emerged in the early 2010s as …

Cardiac fibrosis is a pathological condition characterized by excessive accumulation of
extracellular matrix components within the myocardium, which can lead to impaired cardiac …

In brief Developing novel therapies to cure and manage endometriosis is a major unmet
need that will benefit over 180 million women worldwide. Results from the current study …

Traditional drug therapy faces challenges such as drug distribution throughout the body,
rapid degradation and excretion, and extensive adverse reactions. In contrast …