Glaucoma is a leading cause of irreversible blindness worldwide. Elevated intraocular
pressure (IOP) is considered to be a predominant risk factor for primary open angle …

Purpose Impairment of the trabecular meshwork (TM) is the principal cause of increased
outflow resistance in the glaucomatous eye. Yes-associated protein (YAP) and …

Non-parenteral drug delivery systems using biomaterials have advantages over traditional
parenteral strategies. For ocular and intranasal delivery, nanoparticulate systems must bind …

Trabecular meshwork (TM) tissue is subjected to constant mechanical stress due to the
ocular pulse created by the cardiac cycle. This brings about alterations in the membrane …

Rho proteins, best known for their regulatory role in actin dynamics, stimulate a variety of
processes important in the control of vascular function, including morphogenesis, migration …

UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl
pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4. The …

Acute inflammatory demyelinating polyneuropathy (AIDP) is an aggressive antibody‐and T‐
cell‐mediated variant of Guillain–Barré Syndrome (GBS), a prominent and debilitating …

Purpose.: Analysis of aqueous humor from patients with primary open-angle glaucoma
(POAG) revealed marked increases in the content of endothelin-1 (ET-1) and transforming …

Purpose.: Statins have been shown to increase aqueous outflow facility. The matricellular
protein SPARC (secreted protein acidic and rich in cysteine) is a critical mediator of aqueous …

Recruitment and trafficking of autoreactive leucocytes across the BNB (blood–nerve barrier)
is an early pathological insult in GBS (Guillain-Barré syndrome), an aggressive autoimmune …