Childhood malignancies are rarely related to known environmental exposures, and it has
become increasingly evident that inherited genetic factors play a substantial causal role …

Adrenocortical carcinoma (adrenal cortex‑derived cancer), an orphan malignancy, is a very
aggressive disease that affects both adults and children with an annual incidence of 1‑2 …

Summary the evolving genomic landscape of ACC requires target validation in terms of
prognostic and predictive value within scientific consortia. Although the existing multiple …

Background Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignant
tumor. Currently, there is a lack of reliable prognostic markers in clinical practice. Extensive …

Background Adrenocortical tumours (ACT) in children are part of the Li-Fraumeni cancer
spectrum and are frequently associated with a germline TP53 pathogenic variant. TP53 p …

With great interest, we read the guidelines authored by the European Reference Network on
Genetic Tumor Risk Syndromes for individuals with Li–Fraumeni syndrome (LFS)[1]. We …

Introduction: As the most distressing complication of sickle cell disease (SCD), pain is
marked by considerable heterogenicity. In this study we explored the potential association of …

Background: Adrenocortical carcinoma (ACC) is an orphan tumor which has poor
prognoses. Therefore, it is of urgent need for us to find candidate prognostic biomarkers and …

Adrenocortical carcinoma (ACC) is a rare cancer in childhood. ACC is frequently associated
with germline TP53 variants, with founder effects especially due to the p. Arg337His …

Very rare tumors (VRTs) in pediatric age represent many different diseases. They present an
annual incidence< 2/1000, 000 and correspond to about 11% of all cancers in patients aged …