The metabotropic glutamate receptors (mGluRs) are family C G-protein-coupled receptors
that participate in the modulation of synaptic transmission and neuronal excitability …

Adolescent brain maturation is characterized by the emergence of executive function
mediated by the prefrontal cortex, eg, goal planning, inhibition of impulsive behavior and set …

Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate
receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 …

Brain development, sensory information processing, and learning and memory processes
depend on Hebbian forms of synaptic plasticity, and on the remodeling and pruning of …

A growing body of evidence indicates that repeated exposure to cocaine leads to profound
changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This …

Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Synaptic plasticity is considered essential for learning and storage of new memories.
Whether all synapses on a given neuron have the same ability to express long-term …

Fragile X syndrome (FXS) is the most common inherited form of mental retardation and a
leading genetic cause of autism. There is increasing evidence in both FXS and other forms …

Beyond direct synaptic communication, neurons are able to talk to each other without
making synapses. They are able to send chemical messages by means of diffusion to target …

Synaptic plasticity is a fundamental property of neurons referring to the activity-dependent
changes in the strength and efficacy of synaptic transmission at preexisting synapses. Such …