Transgenerational Effects of Arsenic Exposure on Learning and Memory in Rats: Crosstalk between Arsenic Methylation, Hippocampal Metabolism, and Histone …

W Hua, X Han, F Li, L Lu, Y Sun… - Environmental …, 2024 - ACS Publications
Arsenic (As) is widely present in the natural environment, and exposure to it can lead to
learning and memory impairment. However, the underlying epigenetic mechanisms are still …

Repeated ethanol exposure and withdrawal alters angiotensin‐converting enzyme 2 expression in discrete brain regions: Implications for SARS‐CoV‐2 …

N Balasubramanian, TD James… - Alcohol: Clinical and …, 2023 - Wiley Online Library
Background People with alcohol use disorder (AUD) may be at higher risk for COVID‐19.
Angiotensin‐converting enzyme 2 (ACE2) and transmembrane serine protease 2 …

ERK signaling is required for nicotine-induced conditional place preference by regulating neuroplasticity genes expression in male mice

L Fan, H Chen, Y Liu, H Hou, Q Hu - Pharmacology Biochemistry and …, 2023 - Elsevier
Nicotine is an addictive compound that interacts with nicotinic acetylcholine receptors
(nAChRs) in the ventral tegmental area (VTA), inducing a release of dopamine in the …

Repeated mild traumatic brain injuries perturb the mitochondrial biogenesis via DNA methylation in the hippocampus of rat

N Balasubramanian, G Jadhav, AJ Sakharkar - Mitochondrion, 2021 - Elsevier
Mitochondrial biogenesis in the brain is impaired in various neurological disorders including
traumatic brain injury (TBI). The long-lasting effects of TBI may be, in part, attributed to …

TET1-induced DNA demethylation in dentate gyrus is important for reward conditioning and reinforcement

S Sagarkar, N Bhat, M Sapre, B Dudhabhate… - Molecular …, 2022 - Springer
Neuroadaptations in neurocircuitry of reward memories govern the persistent and
compulsive behaviors. The study of the role of hippocampus in processing of reward …

Gut Microbiota Regulates Epigenetic Remodelling in the Amygdala: A Role in Repeated Mild Traumatic Brain Injury (rMTBI)-Induced Anxiety

G Jadhav, BB Dudhabhate, DM Kokare… - Molecular …, 2023 - Springer
Gut microbiota serves in the development and maintenance of phenotype. However, the
underlying mechanisms are still in its infancy. The current study shows epigenetic …

Response of nitrergic system in the brain of rat conditioned to intracranial self‐stimulation

AG Choudhary, SN Awathale… - Journal of …, 2024 - Wiley Online Library
The role of nitrergic system in modulating the action of psychostimulants on reward
processing is well established. However, the relevant anatomical underpinnings and scope …

AMPA and NMDA receptors in dentate gyrus mediate memory for sucrose in two port discrimination task

S Sagarkar, N Bhat, D Rotti, NK Subhedar - Hippocampus, 2024 - Wiley Online Library
Although the phenomenon of memory formation and recall associated with the use of
psychotropic drugs has been extensively studied, mechanisms underlying memories for …

[HTML][HTML] Neuroplastic changes in the superior colliculus and hippocampus in self-rewarding paradigm: importance of visual cues

SN Awathale, AM Waghade, HM Kawade… - Molecular …, 2021 - Springer
Coincident excitation via different sensory modalities encoding objects of positive salience is
known to facilitate learning and memory. With a view to dissect the contribution of visual …

Neuropeptide CART modulates dopamine turnover in the nucleus accumbens: Insights into the anatomy of rewarding circuits

SN Awathale, AG Choudhary… - Journal of …, 2021 - Wiley Online Library
Neuropeptide cocaine‐and amphetamine‐regulated transcript (CART) is known to influence
the activity of the canonical mesolimbic dopaminergic pathway and modulate reward …