Major insights into the phylogenetic distribution, biochemistry, and evolutionary significance
of organelles involved in ATP synthesis (energy metabolism) in eukaryotes that thrive in …

Amoebiasis is the second leading cause of death from parasitic disease worldwide. The
causative protozoan parasite, Entamoeba histolytica, is a potent pathogen. Secreting …

A new hypothesis for the origin of eukaryotic cells is proposed, based on the comparative
biochemistry of energy metabolism. Eukaryotes are suggested to have arisen through …

The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy
humans and animals, and causes an unrelenting infection in immunocompromised …

The presence of shared conserved insertion or deletions (indels) in protein sequences is a
special type of signature sequence that shows considerable promise for phylogenetic …

The endosymbiotic theory for the origin of mitochondria requires substantial modification.
The three identifiable ancestral sources to the proteome of mitochondria are proteins …

Metronidazole is one of the rare examples of a drug developed against a parasite which has
since gained broad use as an antibacterial agent (24). Brieffy, at Rhone-Poulenc labs in …

Diplomonads, parabasalids, as represented by trichomonads, and microsporidia are three
protist lineages lacking mitochondria that branch earlier than all other eukaryotes in small …

The adhE2 gene of Clostridium acetobutylicum ATCC 824, coding for an aldehyde/alcohol
dehydrogenase (AADH), was characterized from molecular and biochemical points of view …

Oxidative decarboxylation of pyruvate to form acetyl–coenzyme A, a crucial step in many
metabolic pathways, is carried out in most aerobic organisms by the multienzyme complex …