Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Nicotinamide adenine dinucleotide (NAD), the cell's hydrogen carrier for redox enzymes, is
well known for its role in redox reactions. More recently, it has emerged as a signaling …

Nicotinamide adenine dinucleotide (NAD+) is an essential substrate for sirtuins and poly
(adenosine diphosphate–ribose) polymerases (PARPs), which are NAD+-consuming …

Empathy—the ability to share the feelings of others—is fundamental to our emotional and
social lives. Previous human imaging studies focusing on empathy for others' pain have …

In the rRNA-based tree of life four bacterial phyla, comprising the Planctomycetes,
Verrucomicrobia, Chlamydiae and Lentisphaerae, form together with the candidate phyla …

Mitochondrial NAD levels influence fuel selection, circadian rhythms, and cell survival under
stress. It has alternately been argued that NAD in mammalian mitochondria arises from …

Members of the phylum Chlamydiae are obligate intracellular bacteria that were discovered
about a century ago. Although Chlamydiae are major pathogens of humans and animals …

Mitochondria use transport proteins of the eukaryotic mitochondrial carrier family (MCF) to
mediate the exchange of diverse substrates, including ATP, with the host cell cytosol …

Reductive genome evolution has purged many metabolic pathways from obligate
intracellular Rickettsia (Alphaproteobacteria; Rickettsiaceae). While some aspects of host …

Pyridine nucleotides are key redox carriers in the soluble phase of all living cells, and both
NAD and NADP play crucial roles in pro-oxidant and antioxidant metabolism. Recent data …