The MRE11–RAD50–NBS1 complex conducts the orchestration of damage signaling and outcomes to stress in DNA replication and repair
Genomic instability in disease and its fidelity in health depend on the DNA damage
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
response (DDR), regulated in part from the complex of meiotic recombination 11 homolog 1 …
Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology
CA Brosey, JA Tainer - Current opinion in structural biology, 2019 - Elsevier
Highlights•SAXS captures architecture and dynamics to elucidate molecular
ensembles.•SAXS advances now probe key thermodynamic and kinetic properties of …
ensembles.•SAXS advances now probe key thermodynamic and kinetic properties of …
Accurate SAXS profile computation and its assessment by contrast variation experiments
A major challenge in structural biology is to characterize structures of proteins and their
assemblies in solution. At low resolution, such a characterization may be achieved by small …
assemblies in solution. At low resolution, such a characterization may be achieved by small …
Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives
JL Berry, V Pelicic - FEMS microbiology reviews, 2015 - academic.oup.com
Prokaryotes have engineered sophisticated surface nanomachines that have allowed them
to colonize Earth and thrive even in extreme environments. Filamentous machineries …
to colonize Earth and thrive even in extreme environments. Filamentous machineries …
Type IV Pili: dynamic bacterial nanomachines
Bacteria and archaea rely on appendages called type IV pili (T4P) to participate in diverse
behaviors including surface sensing, biofilm formation, virulence, protein secretion and …
behaviors including surface sensing, biofilm formation, virulence, protein secretion and …
The structure and mechanism of the bacterial type II secretion system
The type II secretion system (T2SS) is a multi‐protein complex used by many bacteria to
move substrates across their cell membrane. Substrates released into the environment …
move substrates across their cell membrane. Substrates released into the environment …
Bidirectional pilus processing in the Tad pilus system motor CpaF
The bacterial tight adherence pilus system (TadPS) assembles surface pili essential for
adhesion and colonisation in many human pathogens. Pilus dynamics are powered by the …
adhesion and colonisation in many human pathogens. Pilus dynamics are powered by the …
The archaellum: an update on the unique archaeal motility structure
SV Albers, KF Jarrell - Trends in microbiology, 2018 - cell.com
Each of the three domains of life exhibits a unique motility structure: while Bacteria use
flagella, Eukarya employ cilia, and Archaea swim using archaella. Since the new name for …
flagella, Eukarya employ cilia, and Archaea swim using archaella. Since the new name for …
The archaellum: how Archaea swim
SV Albers, KF Jarrell - Frontiers in Microbiology, 2015 - frontiersin.org
Recent studies on archaeal motility have shown that the archaeal motility structure is unique
in several aspects. Although it fulfills the same swimming function as the bacterial flagellum …
in several aspects. Although it fulfills the same swimming function as the bacterial flagellum …
The molecular mechanism of the type IVa pilus motors
Type IVa pili are protein filaments essential for virulence in many bacterial pathogens; they
extend and retract from the surface of bacterial cells to pull the bacteria forward. The motor …
extend and retract from the surface of bacterial cells to pull the bacteria forward. The motor …