Clear cell renal cell carcinoma ontogeny and mechanisms of lethality
The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and
progression are being increasingly defined. The TRACERx Renal studies and others that …
progression are being increasingly defined. The TRACERx Renal studies and others that …
[HTML][HTML] The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF
S Ghalehbandi, J Yuzugulen, MZI Pranjol… - European Journal of …, 2023 - Elsevier
Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …
between health and disease. In spite of its central role in physiological homeostasis, it …
[HTML][HTML] Nivolumab plus ipilimumab versus sunitinib in advanced renal-cell carcinoma
RJ Motzer, NM Tannir, DF McDermott… - … England Journal of …, 2018 - Mass Medical Soc
Background Nivolumab plus ipilimumab produced objective responses in patients with
advanced renal-cell carcinoma in a pilot study. This phase 3 trial compared nivolumab plus …
advanced renal-cell carcinoma in a pilot study. This phase 3 trial compared nivolumab plus …
Renal cell carcinoma
Renal cell carcinoma (RCC) denotes cancer originated from the renal epithelium and
accounts for> 90% of cancers in the kidney. The disease encompasses> 10 histological and …
accounts for> 90% of cancers in the kidney. The disease encompasses> 10 histological and …
Systemic therapy for metastatic renal-cell carcinoma
TK Choueiri, RJ Motzer - New England Journal of Medicine, 2017 - Mass Medical Soc
Kidney cancers have been extensively studied, and insights from an increased
understanding of tumor biology have led to increases in survival rates. Therapies aimed at …
understanding of tumor biology have led to increases in survival rates. Therapies aimed at …
Immune checkpoint inhibitors in renal cell carcinoma: molecular basis and rationale for their use in clinical practice
F Lasorsa, NA di Meo, M Rutigliano, M Milella, M Ferro… - Biomedicines, 2023 - mdpi.com
Renal cell carcinoma (RCC) is the seventh most common cancer in men and the ninth most
common cancer in women worldwide. There is plenty of evidence about the role of the …
common cancer in women worldwide. There is plenty of evidence about the role of the …
Targeting the microenvironment in solid tumors
Tumorigenesis is a complex and dynamic process involving different cellular and non-
cellular elements composed of tumor microenvironment (TME). The interaction of TME with …
cellular elements composed of tumor microenvironment (TME). The interaction of TME with …
Resistance to systemic therapies in clear cell renal cell carcinoma: mechanisms and management strategies
P Makhov, S Joshi, P Ghatalia, A Kutikov… - Molecular cancer …, 2018 - AACR
Renal cell carcinoma (RCC) is the most common form of kidney cancer. It is categorized into
various subtypes, with clear cell RCC (ccRCC) representing about 85% of all RCC tumors …
various subtypes, with clear cell RCC (ccRCC) representing about 85% of all RCC tumors …
Ten years of anti-vascular endothelial growth factor therapy
N Ferrara, AP Adamis - Nature reviews Drug discovery, 2016 - nature.com
The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …
normal and pathological angiogenesis, has revealed innovative therapeutic approaches in …
Renal cancer
U Capitanio, F Montorsi - The Lancet, 2016 - thelancet.com
The diagnosis and management of renal cell carcinoma have changed remarkably rapidly.
Although the incidence of renal cell carcinoma has been increasing, survival has improved …
Although the incidence of renal cell carcinoma has been increasing, survival has improved …