Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …

Background and purpose Zuojin capsule (ZJC), a classical prescription, is outstanding in
improving the conditions of patients with gastrointestinal diseases and colorectal cancer …

Tuberous sclerosis (TS) is a rare autosomal dominant genetic multisystem disease caused
by mutations in either the TSC1 or TSC2 gene and results in the growth of non-cancerous …

The tuberous sclerosis complex 1 (TSC1) is a critical upstream regulator of autophagy.
Nevertheless, the detailed molecular mechanism of TSC1 and its function in crustacean are …

Oncogenic overexpression of MYC leads to the fatal deregulation of signaling pathways,
cellular metabolism, and cell growth. MYC rearrangements are found frequently among non …

La vía PI3K/AKT/mTOR participa en múltiples procesos celulares fundamentales para la
célula. Algunas mutaciones genéticas de los componentes de esta vía se han asociado a …

Background and Purpose: Emodin, a compound derived from rhubarb and various
traditional Chinese medicines, exhibits a range of pharmacological actions, including …

Chronic kidney disease is the main cause of mortality in patients with tuberous sclerosis
complex (TSC) disease. The mechanisms underlying TSC cystic kidney disease remain …

Human N-myristoyltransferases (NMTs) catalyze N-terminal protein myristoylation, a
modification regulating membrane trafficking and interactions of> 100 proteins. NMT is a …