Amphiphilic small molecule antimicrobials: From cationic antimicrobial peptides (CAMPs) to mechanism-related, structurally-diverse antimicrobials

J Yuan, J Wang, X Li, Y Zhang, J Xian, C Wang… - European Journal of …, 2023 - Elsevier
Bacterial infections are characterized by their rapid and widespread proliferation, leading to
significant morbidity. Despite the availability of a variety of antimicrobial drugs, the …

Smart multifunctional polymer systems as alternatives or supplements of antibiotics to overcome bacterial resistance

D Pranantyo, K Zhang, Z Si, Z Hou… - …, 2022 - ACS Publications
In recent years, infectious diseases have again become a critical threat to global public
health largely due to the challenges posed by antimicrobial resistance. Conventional …

Facial amphiphilic naphthoic acid-derived antimicrobial polymers against multi-drug resistant gram-negative bacteria and biofilms

LB Kurnaz, S Barman, X Yang, C Fisher, FW Outten… - Biomaterials, 2023 - Elsevier
Inspired by the facial amphiphilic nature and antimicrobial efficacy of many antimicrobial
peptides, this work reported facial amphiphilic bicyclic naphthoic acid derivatives with …

An optimized analog of antimicrobial peptide Jelleine-1 shows enhanced antimicrobial activity against multidrug resistant P. aeruginosa and negligible toxicity in vitro …

J Zhou, L Zhang, Y He, K Liu, F Zhang, H Zhang… - European Journal of …, 2021 - Elsevier
Due to the threat of escalating multi-drug resistant gram-negative bacteria to human health
and life, novel antimicrobial agents against gram-negative pathogens are urgently needed …

Unlocking the bacterial membrane as a therapeutic target for next-generation antimicrobial amphiphiles

D Mehta, V Saini, B Aggarwal, A Khan… - Molecular Aspects of …, 2021 - Elsevier
Gram-positive bacteria like Enterococcus faecium and Staphylococcus aureus, and Gram-
negative bacteria like Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …

Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance

D Mehta, V Saini, A Bajaj - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Fungal infections cause severe and life-threatening complications especially in
immunocompromised individuals. Antifungals targeting cellular machinery and cell …

Cholic acid-peptide conjugates as potent antimicrobials against interkingdom polymicrobial biofilms

S Gupta, J Thakur, S Pal, R Gupta… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
Interkingdom polymicrobial biofilms formed by Gram-positive Staphylococcus aureus and
Candida albicans pose serious threats of chronic systemic infections due to the absence of …

Microbial interkingdom biofilms and the quest for novel therapeutic strategies

K Van Dyck, RM Pinto, D Pully, P Van Dijck - Microorganisms, 2021 - mdpi.com
Fungal and bacterial species interact with each other within polymicrobial biofilm
communities in various niches of the human body. Interactions between these species can …

Cleavable Amphiphilic Biocides with Ester-Bearing Moieties: Aggregation Properties and Antibacterial Activity

K De, R Dey, Y Acharya, VK Aswal, J Haldar - Langmuir, 2024 - ACS Publications
The rise of multidrug-resistant bacterial infections and the dwindling supply of newly
approved antibiotics have emerged as a grave threat to public health. Toward the ever …

Recent advances in steroid amino acid conjugates: Old scaffolds with new dimensions

P Singla, DB Salunke - European Journal of Medicinal Chemistry, 2020 - Elsevier
Hybrid chemical compounds formed by conjugation of two or more bioactive molecules have
shown wide variety of applications in biology, microelectronics as well as material sciences …