Angiogenesis and disruption of liver vascular architecture have been linked to progression
to cirrhosis and liver cancer (HCC) in chronic liver diseases, which contributes both to …

Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the
angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to …

Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying
drug approved to date. We discovered LNA043—a derivative of angiopoietin-like 3 …

Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of
lipids. Inactivation of ANGPTL3, a gene located in an intron of DOCK7, results in very low …

Cells released from primary tumors seed metastases to specific organs by a nonrandom
process, implying the involvement of biologically selective mechanisms. Based on clinical …

Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment
is a key event in cancer development and progression. In the last decade, emerging …

Triglycerides and cholesterol circulate in the bloodstream as part of various lipoprotein
particles. Three members of the angiopoietin-like (ANGPTL) protein family—ANGPTL3 …

Recent studies of obesity have provided new insights into the mechanisms underlying
insulin resistance and metabolic dysregulation. Numerous efforts have been made to …

Recently, a family of proteins structurally similar to the angiogenic regulating factors
angiopoietins was identified and designated “angiopoietin-like proteins”(Angptls). Encoded …

Natural bone is a highly vascularized tissue that relies on blood vessels for the timely supply
of blood and nutrition to maintain skeletal integrity.[1, 2] Thus in bone regeneration the newly …