Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is
regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears …

Ca2+ overload-induced mitochondrial dysfunction is considered as a major contributing
factor in the pathogenesis of alcohol-associated liver disease (ALD). However, the initiating …

Allotopic expression is the functional transfer of an organellar gene to the nucleus, followed
by synthesis of the gene product in the cytosol and import into the appropriate organellar …

Spatial and genomic heterogeneity of tumors are crucial factors influencing cancer
progression, treatment, and survival. However, a technology for direct mapping the clones in …

Fluctuations in the number of regulatory molecules and differences in timings of molecular
events can generate variation in gene expression among genetically identical cells in the …

Mitochondrial DNA (mtDNA) mutations have been identified in various human cancers,
including thyroid cancer. However, the relationship between mtDNA and thyroid cancer …

Although it has gained more attention in recent years, the relationship between breast
cancer (BC) and mitochondrial oxidative phosphorylation (OXPHOS) is still not well …

This comprehensive review delves into the complex interplay between mitochondrial gene
defects and pancreatic cancer pathogenesis through a multiomics approach. By …

Background Emerging evidence confirms that lncRNAs (long non-coding RNAs) are
potential biomarkers that play vital roles in tumors. ZNF582-AS1 is a novel lncRNA that …

Mitochondria are major organelles involved in several processes related to energy supply,
metabolism, and cell proliferation. The mitochondria function is transcriptionally regulated by …