Cancer immunotherapy has transformed traditional treatments, with immune checkpoint
blockade being particularly prominent. However, immunotherapy has minimal benefit for …

Cancer-associated fibroblasts (CAFs) are an important component of the tumor
microenvironment that are involved in multiple aspects of cancer progression and …

Tumor growth is not only dictated by events involving tumor cells, but also by the
environment they reside in, the so-called tumor microenvironment (TME). In the TME, cancer …

Radiopharmaceutical therapy (RPT) is defined as the delivery of radioactive atoms to tumor-
associated targets. In RPT, imaging is built into the mode of treatment since the …

Utilizing targeted therapies capable of reducing cancer metastasis, targeting chemoresistant
and self-renewing cancer stem cells, and augmenting the efficacy of systemic …

In the past decade, radiation therapy (RT) entered the era of personalized medicine,
following the striking improvements in radiation delivery and treatment planning …

Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest tumors
owing to its robust desmoplasia, low immunogenicity, and recruitment of cancer-conditioned …

Metabolic reprogramming'Warburg effect'and immune checkpoint signaling are
immunosuppressive hallmarks of triple-negative breast cancer (TNBC) contributing to the …

Acidosis of the tumor microenvironment is a hallmark of tumor progression and has emerged
as an essential biomarker for cancer diagnosis, prognosis, and evaluation of treatment …

Production of nitric oxide (NO) has been demonstrated in several malignancies, however its
role remains not fully understood, specifically in relation to the metabolic and functional …