Background The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin),
receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1 …

The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell
proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF …

New incidence of prostate cancer is a major public health issue in the Western world, and
has been rising in other areas of the globe in recent years. In an effort to understanding the …

The insulin-like growth factor (IGF) family of ligands, binding proteins and receptors is an
important growth factor system involved in both the development of the organism and the …

IGF-I receptor (IGF-IR) signaling and functions are mediated through the activities of a
complex molecular network of positive (eg., type I IGF) and negative (eg., the type II IGF …

Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

Several decades of basic and clinical research have demonstrated that there is an
association between the insulin-like growth factors (IGFs) and neoplasia. We begin with a …

The androgen receptor (AR) is highly expressed in androgen-dependent and recurrent
prostate cancer (CaP) suggesting it has a role in the growth and progression of CaP …

Carrying excess body fat is a leading cause of cancer. Epidemiologic evidence gives strong
clues about the mechanisms that link excess adiposity to risk for several cancer sites. For …

Insulin-like growth factors and their receptor (IGF-1R) have been implicated in cancer
pathophysiology. We demonstrate that IGF-1R is universally expressed in various …